Intercellular Recognition and Adhesion in Desmosomes

  • Gary Gorbsky
Part of the Developmental Biology book series (DEBO, volume 3)


The regulation of intercellular adhesion has been long believed to have important roles in embryonic morphogenesis, in the maintenance of normal adult tissues, and in cancer. Intercellular adhesion is mediated by components of the plasma membrane and the extracellular matrix. In certain regions on the apposed plasma membranes of two cells, surface molecules coalesce to form ultrastructurally recognizable intercellular junctions. These are presumed to be sites of enhanced intercellular adhesion. The purpose of this chapter is to describe the current state of knowledge and methodology in understanding the biogenesis and function of the major adhesive intercellular junctions of vertebrates.


Basal Lamina Intercellular Adhesion Intercellular Junction Rous Sarcoma Virus Desmosomal Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Gary Gorbsky
    • 1
  1. 1.High Voltage Electron Microscopy Laboratory and Department of Molecular BiologyUniversity of Wisconsin—MadisonMadisonUSA

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