Growth Control in Capillary Endothelium

  • Judah Folkman
Part of the Developmental Biology book series (DEBO, volume 3)


A network of capillary blood vessels supplies the nutritional needs of every part of the body. The endothelial cells lining these capillaries comprise a tissue of approximately 2 kg in a 70-kg human. These endothelial cells perform a variety of metabolic, immunological, and hemostatic functions (Ryan and Ryan, 1981; Pober et al., 1983; Loskutoff and Levin, 1984), but they rarely proliferate. Their rate of replication is usually so low that turnover times are measured in thousands of days (Folkman and Cotran, 1976; Denekamp and Hobson, 1984). By contrast, the turnover of intestinal mucosa is approximately 3 days and that of bone marrow about 5 days. However, with an appropriate stimulus, capillary endothelial cells can begin rapid proliferation and achieve turnover times almost as fast as bone marrow cells. Capillary endothelial cells proliferate most actively during angiogenesis, i.e., when new capillaries are being formed.


Mast Cell Fibroblast Growth Factor Chick Embryo Angiogenic Factor Capillary Endothelial Cell 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Judah Folkman
    • 1
    • 2
  1. 1.Department of SurgeryChildren’s HospitalBostonUSA
  2. 2.Department of Surgery, Department of Anatomy and Cellular BiologyHarvard Medical SchoolBostonUSA

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