The Cell Surface and Cancer Metastasis

  • George Poste
  • Russell Greig
Part of the Developmental Biology book series (DEBO, volume 3)


The cell biology of cancer metastasis has been studied in considerable detail over the past 10 years, yielding many important new insights into the patho genesis of this important and life-threatening disease (reviewed by Poste and Fidler, 1980; Poste, 1982; Nicolson and Milas, 1984). By contrast, efforts at understanding the underlying biochemistry and molecular biology of this process have been limited and largely unsuccessful. A much greater understanding of the molecular mechanisms responsible for the expression of the metastatic phenotype will be required if we are to develop novel and productive approaches to the therapy of metastatic disease by any approach other than random and semiempirical screening, which hitherto has made little impact in developing anticancer drugs against the more common solid malignancies of man. In the absence of any obvious biochemical target to guide the direction of such an endeavor, it is becoming increasingly clear that the process of identifying molecular properties that correlate either qualitatively or quantitatively with metastatic potential will be a prolonged and challenging task and with no guarantee that any correlation, once identified, will be causal or will offer a suitably “unique” and pharmacologically exploitable target for the design of new therapeutic agents directed against it.


Metastatic Cell Metastatic Process Metastatic Phenotype Tumor Cell Population Metastatic Behavior 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • George Poste
    • 1
  • Russell Greig
    • 1
  1. 1.Smith Kline and French LaboratoriesPhiladelphiaUSA

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