Cell Traction in Relationship to Morphogenesis and Malignancy

  • Albert K. Harris
Part of the Developmental Biology book series (DEBO, volume 3)


If we explant a fragment of embryonic tissue into a suitable culture medium on a reasonably adhesive substratum such as glass, the component cells of the tissue will crawl actively over this substratum, almost as if they were so many amoebae. Concerning this familiar phenomenon, three questions arise: How do the cells propel themselves? What functions does their propulsive mechanism serve in the development and maintenance of the body? Why doesn’t the loco motion of cells disrupt and disperse the proper histological arrangements of cells inside the body?


Chinese Hamster Ovary Cell Silicone Rubber Traction Force Reverse Transformation Cell Traction 
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  1. Elsdale, T., and Bard, J., 1972, Collagen substrata for studies on cell behavior, J. Cell Biol. 54:626– 637.PubMedCrossRefGoogle Scholar
  2. Gompel, C., 1978, An Atlas of Diagnostic Cytology ,Wiley, New York.Google Scholar
  3. Harris, J. K., 1978, A photoelastic substrate technique for dynamic measurements of forces exerted by moving organisms, J. Microsc. 114:219–228.PubMedCrossRefGoogle Scholar
  4. Hsie, A. W., and Puck, T. T., 1971, Morphological transformation of Chinese hamster cells by dibutyryl adenosine cyclic 3’ : 5’-monophosphate and testosterone, Proc. Natl. Acad. Sci. USA 68:358–361.PubMedCrossRefGoogle Scholar
  5. Izzard, C. S., and Lochner, L. R., 1980, Formation of cell to substrate contacts during fibroblast motility: An interference reflexion study, J. Cell Sci. 42:81–116.PubMedGoogle Scholar
  6. James, D. W., and Taylor, J. F ,1969, The stress developed by sheets of chick fibroblasts in vitro, Exp. Cell Res. 54:107–110.PubMedCrossRefGoogle Scholar
  7. Jessop, H. T., and Harris, F. C., 1960, Photoelasticity, Principles and Methods ,Dover, New York.Google Scholar
  8. Johnson, G. S., Friedman, R. M., and Pastan, I., 1971, Restoration of several morphological charac teristics of normal fibroblasts in sarcoma cells treated with adenosine-3’ : 5’-cyclic monophosphate and its derivatives, Proc. Natl. Acad. Sci. USA 68:425–429.PubMedCrossRefGoogle Scholar
  9. Katzberg, A. A., 1951, Distance as a factor in the development of attraction fields between growing tissues in culture, Science 114:431–432.PubMedCrossRefGoogle Scholar
  10. Leader, W. M., Stopak, D., and Harris, A. K., 1983, Increased contractile strength and tightened adhesions to the substratum result from reverse transformation of CHO cells by dibutyryl cyclic adenosine monophosphate, J. Cell Sci. 64:1–11.PubMedGoogle Scholar
  11. Phillips, H. M., and Davis, G. S., 1978, Liquid-tissue mechanics in amphibian gastrulation. Germ layer assembly in Rana pipiens, Am. Zool. 18:81–93.Google Scholar
  12. Phillips, H. M., and Steinberg, M. S., 1978, Embryonic tissues as elasticoviscous liquids. I. Rapid and slow shape changes in centrifuged cell aggregates, J. Cell Sci. 30:1–20.PubMedGoogle Scholar
  13. Steinberg, B. M., Smith, K., Colozzo, M., and Pollack, R., 1980, Establishment and transformation diminish the ability of fibroblasts to contract a native collagen gel, J. Cell Biol. 87:304–308.PubMedCrossRefGoogle Scholar
  14. Stopak, D., and Harris, A. K., 1982, Connective tissue morphogenesis by fibroblast traction. I. Tissue culture observations, Dev. Biol. 90:383–398.PubMedCrossRefGoogle Scholar
  15. Weiss, P., 1952, “Attraction fields” between growing tissue cultures, Science 115:293–295.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Albert K. Harris
    • 1
  1. 1.Department of BiologyUniversity of North CarolinaChapel HillUSA

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