Cell Traction in Relationship to Morphogenesis and Malignancy
If we explant a fragment of embryonic tissue into a suitable culture medium on a reasonably adhesive substratum such as glass, the component cells of the tissue will crawl actively over this substratum, almost as if they were so many amoebae. Concerning this familiar phenomenon, three questions arise: How do the cells propel themselves? What functions does their propulsive mechanism serve in the development and maintenance of the body? Why doesn’t the loco motion of cells disrupt and disperse the proper histological arrangements of cells inside the body?
KeywordsChinese Hamster Ovary Cell Silicone Rubber Traction Force Reverse Transformation Cell Traction
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