Growth Cone Guidance and Cell Recognition in Insect Embryos
In contrast to the complex central nervous system of most vertebrates, the insect CNS is relatively simple. The grasshopper CNS, for example, consists of a brain and a chain of segmental ganglia, each of which contains about 1000 neurons. Most of these neurons can be individually identified according to their unique axonal and dendritic morphology and their unique pattern of synaptic connections. This notion of unique identified neurons first arose dur ing the nineteenth century with descriptions of giant axons, which were repeatedly located in particular regions of the nerve cord. With the advent of intracellular dye-injection techniques (e.g., Stretton and Kravitz, 1968; Pitman et al., 1972; Stewart, 1978), many neurons became individually identified according to the location of their axons and dendrites in the neuropil and connectives. The spatial relationship of these processes to one another within the neuropil was then explored (e.g.,Tyrer and Gregory, 1982); it was shown that the axons and dendrites of identified neurons run in particular regions of specific tracts and commissures.
KeywordsGrowth Cone Drosophila Embryo Neuronal Growth Cone Selective Affinity Neuronal Surface
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- Bastiani, M. J., and Goodman, C. S., 1984b, The first growth cones in the central nervous system of the grasshopper embryo, pp. 63–84, in: CeJJuJar and Molecular Approaches to Neuronal Development (I. Black, ed.), Plenum Press, New York.Google Scholar
- Bastiani, M. J., duLac, S., and Goodman, C. S., 1985b, The first growth cones in insect embryos: Model system for studying the development of neuronal specificity, pp. 149–174, in: Model Neural Networks and Behavior [A. Selverston, ed.], Plenum Press, New York.Google Scholar
- Goodman, C. S., Raper, J. A., Ho, R., and Chang, S. ,1982, Pathfinding by neuronal growth cones in grasshopper embryos, Symp. Soc. Dev. Biol. 40:275–316.Google Scholar
- Raper, J. A. ,Bastiani, M. J. ,and Goodman, C. S., 1983c, Guidance of neuronal growth cones: Selective fasciculation in the grasshopper embryo, Cold Spring Harbor Symp. Quant. Biol. Mol. Neurobiol. 48:587–598.Google Scholar