Extracellular Matrix Involvement in Epithelial Branching Morphogenesis
Branching morphogenesis is a major developmental process used by a large array of embryonic organs. Examples of organs whose development involves branching morphogenesis include submandibular, sublingual, and parotid sali vary glands, mammary glands, lungs, pancreas, and kidneys. In each case, an epithelium undergoes repeated branching activity, in concert with mitotic growth, that results in the formation of an organ-specific pattern of clefts or branch points and the generation of large amounts of epithelial surface area for the available amount of organ space. The advantage would appear to be that epithelial surface area for such functions as secretory activity and gas exchange is maximized, resulting in highly efficient compact organs.
KeywordsBasal Lamina Anionic Site Proteoglycan Synthesis Lamina Densa LACA Effect
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