Gap Junctions in Development

  • Jean-Paul Revel
Part of the Developmental Biology book series (DEBO, volume 3)


The concept of a multicellular organism as an assemblage of cells that work together harmoniously for the good of the whole organism is well established. Over the past 15 years, however, it has become increasingly clear that the individual cells of multicellular animals are not as self-sufficient and independent of each other as once had been believed. Channels that exist between virtually all neighboring cells permit such widespread intercellular exchanges of low-molecular-weight materials that they must be considered syncytial with respect to small molecules. The specialized areas of the membrane that permit these exchanges are clusters of channels whose permeability is limited only by molecular size of the permeant (Simpson et al., 1977; Flagg-Newton et al., 1979), known collectively as gap junctions. Only in the case of molecules close to the exclusion limit can one detect selectivity (Brink and Dewey, 1980).


Intercellular Junction Electrical Coupling Cell Coupling Lens Fiber Junctional Permeability 
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  1. Anderson, E., and Albertini, D. F., 1976, Gap junctions between the oocyte and the companion follicle cells in the mammalian ovary, J. Cell Biol. 71:680–686.PubMedCrossRefGoogle Scholar
  2. Bellairs, R., Breathnach, A. S. ,and Gross, M., 1975, Freeze fracture replication of junctional com plexes in unincubated and incubated chick embryos, Cell Tissue Res. 162:235–252.PubMedCrossRefGoogle Scholar
  3. Benedetti, E. L., Dunia, I. ,and Bloemendal, H., 1974, Development of junctions during differentiation of lens fibers, Proc. Natl.. Acad. Sci. USA 71:5073–5077.PubMedCrossRefGoogle Scholar
  4. Benedetti, E. L., Duria, I. ,Ramackers, F. C. S., and Kibbelaar, M. A., 1981, Lenticular plasma membranes and cytoskeleton, in: Molecular and Cellular Biology of the Eye Lens (H. Bloemendal, ed.), pp. 137–188, Wiley, New York.Google Scholar
  5. Bennett, M. V. L., 1973, Function of electrotonic junctions in embryonic and adult tissues, Fed. Proc. 32:65–75.PubMedGoogle Scholar
  6. Bennett, M. V. L., Spira, M. E., and Spray, D. C., 1978, Permeability of gap junctions between embryonic cells of Fundulus: A revaluation, Dev. Biol. 65:114–125.PubMedCrossRefGoogle Scholar
  7. Bloemendal, H. A. ,Zweers, F., Vermorken, I. ,Dunia, I., and Benedetti, E. L., 1972, The plasma membranes of eye lens fibers. Biochemical and structural characterization, Cell Diff. 1:91–106.CrossRefGoogle Scholar
  8. Bok, D., Dockstader,J., and Horwitz,J., 1982, Immunocytochemical localization of the lens main intrinsic polvpeptide (MIP261 in communicatine hinntinns. I Cell Rinl 92 :213–220Google Scholar
  9. Brink, P. R., and Dewey, M. M. ,1980, Evidence for fixed charge in the nexus, Nature (Lond.) 285:101–103.CrossRefGoogle Scholar
  10. Caspar, D. L. D., Goodenough, D. A. ,Makowski, I., and Phillips, W. C.,1977, Gap junction structures. I. Correlated electron microscopy and X-ray diffraction, J. Cell Biol. 74:605–628.PubMedCrossRefGoogle Scholar
  11. Caveney, S. ,1974, Intercellular communication in a positional field: movement of small ions between insect epidermal cells, Dev. Biol. 40:311–322.PubMedCrossRefGoogle Scholar
  12. Coons, L. W., and Espey, L. L., 1977, Quantitation of nexus junctions in the granulosa cell layer of rabbit ovarian follicles during ovulation, J. Cell Biol. 74:321–325.PubMedCrossRefGoogle Scholar
  13. Crick, F. ,1970, Diffusion in embryogenesis, Nature (Lond.) 225:420–422.CrossRefGoogle Scholar
  14. Daniel, E. E., Daniel, V. P., Duchon, G., and Garfield, R. E., 1976, Is the nexus necessary for cell-toell coupling of smooth muscle?, J. Membr. Biol. 28:207–239.PubMedCrossRefGoogle Scholar
  15. De Laat, S. W., Tertoolen, L. G., and Grimmlikhuijzen, C. J. ,1980, No junctional communication between epithelial cells in Hydra, Nature (Lond.) 288:711–713.CrossRefGoogle Scholar
  16. Dixon, J. S. ,and Cronly-Dillon, J. R., 1972, The fine structure of developing retina in Xenopus Jaevis, J. Embryol. Exp. Morphol. 28:659–666.PubMedGoogle Scholar
  17. Ducibella, J., Albertini, D., Anderson, E., and Biggers, J. D., 1975, The preimplantation mammalian embryo: Characterization of intercellular junctions and their appearance during development, Dev. Biol. 47:231–250.CrossRefGoogle Scholar
  18. Duguid, J., and Revel, J. P. ,1976, The protein components of the gap junction, Cold Spring Harbor Symp. Quant. Biol. 40:45–47.PubMedCrossRefGoogle Scholar
  19. Elias, P. M. ,Grayson, S., Caldwell, T. M. ,and McNutt, N. S., 1980, Gap junction proliferation in retinoic acid-treated human basal cell carcinoma, Lab. Invest. 42:469–474.PubMedGoogle Scholar
  20. Elias, P. M., Grayson, S., Gross, E. G., Peck, G. L., and McNutt, N. S. ,1981, Influence of topical and systemic retinoids on basal cell carcinoma membranes, Cancer 48:932–938.PubMedCrossRefGoogle Scholar
  21. Eppig, J. J., Freter, R. R., Ward-Bailey, P. F., and Schultz, R. M., 1983, Inhibition of oocyte maturation in the mouse: Participation of cAMP, steroid hormones, and a putative maturation-inhibitory factor, Dev. Biol. 100:39–49.PubMedCrossRefGoogle Scholar
  22. Epstein, M. L., and Gilula, N. B., 1977, A study of communication specificity between cells in culture, J. Cell Biol. 75:769–787.PubMedCrossRefGoogle Scholar
  23. Fallon, R. F., and Goodenough, D. A. ,1981, Five hour half-life of mouse liver gap junction protein, J. Cell Biol. 90:521–525.PubMedCrossRefGoogle Scholar
  24. Finbow, M., Yancey, S. B., Johnson, R., and Revel, J. P., 1980, Independent lines of evidence suggesting a major junctional protein with a MW of 26000, Proc. Natl. Acad. Sci. USA 77:970– 974.PubMedCrossRefGoogle Scholar
  25. Flagg-Newton, J., Simpson, I., and Loewenstein, W. R., 1979, Permeability of the cell-cell membrane channels in mammalian cell junction, Science 205:404–409.PubMedCrossRefGoogle Scholar
  26. Fraser, S. E., and Bode, H. R., 1981. Epithelial cells of Hydra are dye coupled, Nature (Lond.) 294:356–358.CrossRefGoogle Scholar
  27. Fujisawa, H., Morioka, H., Watanabe, K., and Nakamura, M., 1976, A decay of gap junctions in association with cell differentiation of neural retina in chick embryo development, J. Cell Sci. 22:585–596.PubMedGoogle Scholar
  28. Garfield, R. E., Merrett, D., and Grover, A. K., 1980, Gap junction formation and regulation in myometrium, Am. J. Physiol. 239:C217–C228.PubMedGoogle Scholar
  29. Georges, D., 1979, Gap and tight junctions in tunicates, Tissue Cell 11:781–792.PubMedCrossRefGoogle Scholar
  30. Gilula, N. B., Epstein, M. L., and Beers, W. H., 1978, Cell-to-cell communication and ovulation. A study of the cumulus-oocyte complex, J. Cell Biol. 78:58–75.PubMedCrossRefGoogle Scholar
  31. Ginzburg, R. D., and Gilula, N. B., 1979, Modulation of cell junctions during differentiation of the chicken otocyst sensory epithelium, Dev. Biol. 68:110–129.CrossRefGoogle Scholar
  32. Goodall, H., and Johnson, M. H., 1982, Use of carboxyfluorescein diacetate to study the formation of permeable channels between mouse blastomeres, Nature (Lond.) 295:524–526.CrossRefGoogle Scholar
  33. Goodenough, D. A. ,1979, Lens gap junctions: A structural hypothesis for nonregulated low-resistance intercellular pathways, Invest. Ophtha Jmol. 18:1104–1122.Google Scholar
  34. Goodenough, D. A. ,Dick, J. S., and Lyons, J. E., 1980, Lens metabolic cooperation: A study of mouse lens transport and permeability visualized with freeze-substitution autoradiography and electron microscopy, J. Cell Biol. 86:576–589.PubMedCrossRefGoogle Scholar
  35. Goodman, C. S., Raper, J. A. ,Ho, R. K., and Chang, S., 1982, Path finding by neuronal growth cones in grasshopper embryos, in: DeveJopmentall Order: Its Origin and ReguJation (S. S. Subtelny and P. B. Green, eds.), pp. 275–316, Alan R. Liss, New York.Google Scholar
  36. Griepp, E. B., Peacock,J., Bernfield, M., and Revel, J. P. ,1978, Morphological and functional correlates of synchronous beating between embryonic heart cell aggregates and layers, Exp. Cell Res. 113:273–282.PubMedCrossRefGoogle Scholar
  37. Gros, D., Mocquard, J. P., Challice, C. E., and Schrevel, J., 1978, Formation and growth of gap junctions in mouse myocardium during ontogenesis: A freeze cleavage study, J. Cell Sci. 30:45–61.PubMedGoogle Scholar
  38. Gros, D., Macquard, J. P. ,Challice, C. E., and Schrevel, J. ,1979, Formation and growth of gap junctions in mouse myocardium during ontogenesis: Quantitative data and their implications on the development of intercellular communication, J. MoJ. Cell Cardiol. 11:543–554.CrossRefGoogle Scholar
  39. Gros, D. B., Nicholson, B.J., and Revel, J. P. ,1983, Comparative analysis of the gap junction protein from rat heart and liver: Is there a tissue specificity of gap junctions? Cell 35:539–549.PubMedCrossRefGoogle Scholar
  40. Hand, A. R., and Gobel, S., 1972, The structural organization of the septate and gap junctions of the Hydra, J. Cell Biol. 52:397–408.PubMedCrossRefGoogle Scholar
  41. Hanna, R. B., Pappas, G. D., and Bennett, M. V. L., 1984, The fine structure of identified electrotonic synapses following increased coupling resistance, Cell Tissue Res. 235:243–249.PubMedCrossRefGoogle Scholar
  42. Harris, A. L., Spray, D. C.,and Bennett, M. V. L., 1983, Control of intercellular communication by voltage dependent gap junction conductance, J. Neurosci. 3:79–100.PubMedGoogle Scholar
  43. Hayes, B. P. ,1977, Intercellular gap junctions in the developing retina and pigment epithelium of the chick, Anat. EmbryoJ. (BerJ.j 151:325–333.CrossRefGoogle Scholar
  44. Hertzberg, E. L., 1980, Biochemical and immunological approaches to the study of gap junctional communication, In Vitro 16:1057–1067.PubMedCrossRefGoogle Scholar
  45. Hertzberg, E. L., and Gilula, N. B., 1979, Isolation and characterization of gap junctions from rat liver, J. Biol. Chem. 254:2138–2147.PubMedGoogle Scholar
  46. Hertzberg, E. L., Anderson, D. J. ,Friedlander, M., and Gilula, N. B., 1982, Comparative analysis of the major polypeptides from liver gap junctions and lens fiber junctions, J. Cell Biol. 92:53– 59.PubMedCrossRefGoogle Scholar
  47. Ito, S., and Loewenstein, W. R., 1969, Ionic communication between early embryonic cells, Dev. Biol 19:228–243.PubMedCrossRefGoogle Scholar
  48. Jacobson, M., 1976, Premature specification of the retina in embryonic Xenopus eyes treated with ionophore X537A, Science 191:288–289.PubMedCrossRefGoogle Scholar
  49. Jaffe, L. F., 1982, Developmental currents, voltages and gradients, in: Developmental Order: Its Origin and Regulation (S. S. Subtelny and P. B. Green, eds.), pp. 183–215, Alan R. Liss, New York.Google Scholar
  50. Kalderon, N., Epstein, M. L., and Gilula, N. B., 1977, Cell to cell communication and myogenesis, J. CeJI Biol. 75:788–806.CrossRefGoogle Scholar
  51. Kelley, R. O., and Fallon, J. F. ,1978, Identification and distribution of gap junctions in the meso derm of the developing chick limb bud, J. Embryol. Exp. Morphol. 46:99–110.PubMedGoogle Scholar
  52. Lane, N., and Skaer, H., H. Le B., 1980, Intercellular junctions in insect tissues, Adv. Insect. Physiol. 15:35–213.CrossRefGoogle Scholar
  53. Lawrence, P. A., and Green, S. M. ,1975, The anatomy of a compartment border. The intersegmental boundary in OncopeJtus, J. Cell Biol. 65:373–383.CrossRefGoogle Scholar
  54. Lawrence, T. S. ,Beers, W. H., and Gilula, N. B., 1978, Transmission of hormonal stimulation by cell-to-cell communication, Nature (Lond.) 272:501–506.CrossRefGoogle Scholar
  55. Lentz, T. L., and Trinkaus, J. P., 1971, Differentiation of the junctional complex of surface cells in the developing FunduJus blastoderm, J. Cell Biol. 48:455–472.PubMedCrossRefGoogle Scholar
  56. Lethias, C.,Garrone, R., and Mazzorana, M., 1983, Fine structure of sponge cell membranes: Comparative study with freeze fracture and conventional thin section methods, Tissue Cell 15:523–535.PubMedCrossRefGoogle Scholar
  57. Lo, C. W., and Gilula, N. B., 1979, Gap junctional communication in the preimplantation mouse embryo, Cell 18:399–409.PubMedCrossRefGoogle Scholar
  58. Loewenstein, W. R., 1967, On the genesis of cellular communication, Dev. Biol. 15:502–520.CrossRefGoogle Scholar
  59. LoPresti, V., Macagno, E. R., and Levinthal, C.,1974, Structure and development of neuronal connections in isogenic organisms: Transient gap junctions between growing optic axons and lamina neuroblasts, Proc. Nstl. Acad. Sci. USA 71:1098–1102.CrossRefGoogle Scholar
  60. Lorber, V., and Rayns, D. G., 1977, Fine structure of the gap junction in the tunicate heart, Cell Tissue Res. 179:169–175.PubMedCrossRefGoogle Scholar
  61. MacWilliams, H. K., 1983, Hydra transplantation phenomena and the mechanism of Hydra head regeneration, Dev. Biol. 96:239–257.CrossRefGoogle Scholar
  62. Maden, M., 1982, Vitamin A and pattern formation in the regenerating limb, Nature (Lond.J 295:672–675.CrossRefGoogle Scholar
  63. Makowski, L., Caspar, D. L. D., Phillips, W. C., and Goodenough, D. A. ,1977, Gap junction structures. II. Analysis of the X-ray diffraction data, J. Cell Biol. 74:629–645.PubMedCrossRefGoogle Scholar
  64. McLachlin, J. ,Caveney, S., and Kidder, G. M. ,1983, Control of gap junction formation in early mouse embryos, Dev. Biol. 98:155–164.PubMedCrossRefGoogle Scholar
  65. Meinhardt, H., 1983, Cell determination boundaries as organizing regions for secondary embryonic fields, Dev. Biol. 96:375–385.PubMedCrossRefGoogle Scholar
  66. Meyer, D.J., Yancey, S. B., and Revel, J. P., 1981, Intercellular communication in normal and regenerating rat liver: A quantitative analysis, J. Cell Biol. 91:505–523.PubMedCrossRefGoogle Scholar
  67. Meyer, R. A. ,and Overton, J. ,1983, Changes in intercellular junctions. I. Embryonic chick liver development, Dev. Biol. 99:172–180.PubMedCrossRefGoogle Scholar
  68. Moscona, A. A. ,and Linser, P., 1983, Developmental and experimental changes in retinal glia cells: Cell interactions and control of phenotype expression and stability, Curr. Topics Dev. Biol. 18:155–188.CrossRefGoogle Scholar
  69. Nicholson, B. J., Hunkapiller, M. W., Grim, L. B., Hood, L. E., and Revel, J.-P., 1981, The rat liver gap junction protein: Properties and partial sequence, Proc. Natl. Acad. Sci. USA 78:7594– 7598.PubMedCrossRefGoogle Scholar
  70. Nicholson, B. J., Gros, D. B., Kent, S. B. H., Hood, L. E., and Revel, J.-P., 1985, The Mr 28,000 gap junction proteins from rat heart and liver are different but related, J. Biol. Chem. 260:6514–6517.PubMedGoogle Scholar
  71. Nicholson, B. J., Takemoto, L.J., Hunkapiller, M. W., Hood, L. E., and Revel, J.-P., 1983, Differences between the liver gap junction protein and lens MIP26 from rat: Implications for tissue speci ficity of gap junctions, Cell 32:967–978.PubMedCrossRefGoogle Scholar
  72. Pannese, E., Luciano, L., Iurato, S., and Reale, E., 1977, Intercellular junctions and other membrane specializations in developing spinal ganglia, J. l/Jtrastruct. Res. 60:169–180.CrossRefGoogle Scholar
  73. Paul, D. L., and Goodenough, D. A., 1983, Preparation, characterization and localization of antisera against bovine MIP26, an integral membrane protein of the lens fiber, J. Cell Biol. 96:625–632.PubMedCrossRefGoogle Scholar
  74. Peracchia, C., 1977, Gap junction. Structural changes after uncoupling, J. Cell Biol. 72:628–645.PubMedCrossRefGoogle Scholar
  75. Peracchia, C., and Peracchia, L. L., 1980a, Gap junction dynamics: reversible effects of divalent cations, J. Cell Biol. 87:708–718.PubMedCrossRefGoogle Scholar
  76. Peracchia, C., and Peracchia, L. L., 1980b, Gap junction dynamics: Reversible effects of hydrogen ions, J. Cell Biol. 87:719–727.PubMedCrossRefGoogle Scholar
  77. Pitts, J. D., 1978, Junctional communication and cellular growth control, in: InterceJJuJar Junctions and Synapses, (J. Feldman, N. B. Gilula, and J. D. Pitts, eds.), pp. 68–80, Chapman and Hall, London.Google Scholar
  78. Potter, D. D., Furshpan, E. J., and Lennox, E. S., 1966, Connections between cells of the developing squid as revealed by electrophysiological methods, Proc. Nstl. Acad. Sci. USA 55:328–335.CrossRefGoogle Scholar
  79. Raviola, E., Goodenough, D. A., and Raviola, G., 1980, Structure of rapidly frozen junctions, J. Cell Biol. 87:273–279.PubMedCrossRefGoogle Scholar
  80. Revel, J.-P., and Brown, S. S., 1976, Cell junctions in development with particular reference to the neural tube, Cold Spring Harbor Symp. Quant. Biol. 40:443–455.PubMedCrossRefGoogle Scholar
  81. Revel, J.-P., and Goodenough, D. A., 1970, Cell coats and intercellular matrix, in: Chemistry and MoJecuJar Biology of the Intercellular Matrix (E. A. Balasz, ed.), pp. 1361–1380, Academic Press, New York.Google Scholar
  82. Revel, J.-P., Levy, L., and Wang, C., 1984, Electron microscope study of junctions in the mesozoa, Cell Tissue Res. (in press).Google Scholar
  83. Rose, B., and Rick, R., 1978, Intracellular pH, intracellular free Ca, and junctional cell-cell coupling, J. Membr. Biol. 44:377–415.PubMedCrossRefGoogle Scholar
  84. Rose, B., Simpson, I., and Loewenstein, W. R., 1977, Calcium ion produces graded changes in permeability cf membrane channels in cell junction, Nature (Lond.) 267:625–627.CrossRefGoogle Scholar
  85. Schaller, H. C., 1973, Isolation and characterization of a low molecular weight substance activating head and bud formation in Hydra, J. EmbryoJ. Exp. MorphoJ. 29:27–38.Google Scholar
  86. Schuetze, S. M., and Goodenough, D. A., 1982, Dye transfer between cells of embryonic chick lens becomes less sensitive to C02 treatment with development, J. Cell Biol. 92:694–705.PubMedCrossRefGoogle Scholar
  87. Sheridan, J. D., 1966, Electrophysiological studies of special connections between cells in the early chick embryo, J. Cell Biol. 31:Cl–C5.CrossRefGoogle Scholar
  88. Simpson, I., Rose, B., and Loewenstein, W. R., 1977, Size limit of molecules permeating the junctional membrane channels, Science 195:294–296.PubMedCrossRefGoogle Scholar
  89. Spiegel, E., and Howard, L., 1983, Development of cell junctions in sea urchin embryos, J. Cell Sci. 62:27–48.PubMedGoogle Scholar
  90. Spray, D. C., Harris, A. L., and Bennett, M. V. L., 1979, Voltage dependence of junctional conductance in early amphibian embryos, Science 204:432–434.PubMedCrossRefGoogle Scholar
  91. Spray, D. C., Harris, A. L., and Bennett, M. V. L., 1981, Gap junctional conductance is a simple and sensitive function of intracellular pH, Science 211:712–715.PubMedCrossRefGoogle Scholar
  92. Summerbell, D., Lewis, J. H., and Wolpert, L., 1973, Positional information in chick limb morphogenesis, Nature (Lond.) 244:492–496.CrossRefGoogle Scholar
  93. Tickle, C., Summerbell, D., and Wolpert, L., 1975, Positional signaling and specification of digits in chick limb morphogenesis, Nature (Lond.) 254:199–202.CrossRefGoogle Scholar
  94. Traub, O., Janssen-Timmen, U., Druge, P. M., Dermietzel, R., and Willecke, K., 1982, Immunological properties of gap junction protein from mouse liver, J. Cell. Biochem. 19:27–44.PubMedCrossRefGoogle Scholar
  95. Tupper, J. T., and Saunders, J. W., 1972, Intercellular permeability in the early Asterias embryo, Dev. Biol. 27:446–554.CrossRefGoogle Scholar
  96. Turin, L., and Warner, A. E., 1977, Carbon dioxide reversibly abolishes ionic communication between cells of early amphibian embryo, Nature (Lond.) 270:56–57.CrossRefGoogle Scholar
  97. Unwin, P. N. T., and Ennis, P. D., 1984, Two configurations of a channel-forming membrane protein, Nature (Lond.) 307:609–613.CrossRefGoogle Scholar
  98. Unwin, P. N. T., and Zampighi, G., 1980, Structure of the junctions between communicating cells, Nature fLond.j 283:545–549.CrossRefGoogle Scholar
  99. Wakeford, R. J. ,1979, Cell contact and positional communication in Hydra, J. Embryol. Exp. Morphol. 54:171–183.PubMedGoogle Scholar
  100. Warner, A. E., and Laurence, P. A. ,1973, Electrical coupling across developmental boundaries in insect epidermis, Nature 245:47–49.PubMedCrossRefGoogle Scholar
  101. Warner, A. E., and Lawrence, P. A. ,1982, Permeability of gap junctions at the segmental border of the insect epidermis, Cell 28:243–252.PubMedCrossRefGoogle Scholar
  102. Warner, A. E., Guthrie, S., and Gilula, N. B., 1984, Antibodies to gap junctional protein selectively disrupt junctional communication in the early amphibian embryo, Nature 311:127–131.PubMedCrossRefGoogle Scholar
  103. Weir, M. P., and Lo, C. W., 1982, Gap junction communication compartments in the DrosophiJa wing disC.,Proc. Natl. Acad. Sci. USA 79:3232–3235.PubMedCrossRefGoogle Scholar
  104. Weir, M. P., and Lo, C. W., 1984, Gap-junctional communication compartments in the DrosophiJa wing imaginal disk, Dev. Biol. 102:130–146.PubMedCrossRefGoogle Scholar
  105. Williams, E. H., and De Haan, R. L., 1981, Electrical coupling among heart cells in the absence of ultrastructurally defined gap junctions, J. Membr. Biol. 60:237–248.PubMedCrossRefGoogle Scholar
  106. Wood, R. L., and Kuda, A. M. ,1980, Formation of junctions in regenerating Hydra Gap junctions, J. UJtrastruct. Res. 73:350–360.CrossRefGoogle Scholar
  107. Yancey, S. B., Easter, D., and Revel, J.-P., 1979, Cytological changes in gap junctions during liver regeneration, J. Ultrastruct. Res. 67:229–242.PubMedCrossRefGoogle Scholar
  108. Yancey, S. B., Nicholson, B. J. ,and Revel, J.-P., 1981, The dynamic state of liver gap junctions, J. Supramol. Struct. Cell Biochem. 16:221–232.PubMedCrossRefGoogle Scholar
  109. Yee, A. G., and Revel, J.-P., 1978, Loss and reappearance of gap junctions in regenerating liver, J. Cell Biol. 78:544–564.CrossRefGoogle Scholar
  110. Zampighi, G., Simon, S., Robertson, J. D., Mcintosh, T., and Costello, M. ,1982, On the organization of isolated bovine lens fiber junctions, J. Cell Biol. 93:175–189.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Jean-Paul Revel
    • 1
  1. 1.Division of BiologyCalifornia Institute of TechnologyPasadenaUSA

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