Paternal Age and Effects on Chromosomal and Specific Locus Mutations and on Other Genetic Outcomes in Offspring

  • Ernest B. Hook


Investigation of effects of parental aging upon genetic effects in offspring is of significance for several reasons: (1) accurate description of these effects will provide appropriate data for genetic counseling and enable informed decisions regarding reproduction; (2) the identification of high-risk groups by age will facilitate efficient delivery of specific secondary “preventive” techniques, (e. g. amniocentesis and prenatal diagnosis) to appropriate target groups in the population — at least to those to whom such techniques are ethically acceptable; (3) identification of the biological processes responsible for the association of aging with adverse genetic outcomes may eventually lead to primary prevention and new methods of secondary prevention.


Down Syndrome Birth Order Fetal Death Turner Syndrome Birth Order Effect 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Ernest B. Hook
    • 1
    • 2
  1. 1.New York State Department of HealthBureau of Maternal and Child HealthAlbanyUSA
  2. 2.Department of PediatricsAlbany Medical CollegeAlbanyUSA

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