Advertisement

Effects of Aging on the Mechanisms of Estrogen Action in Rat Uterus

  • George S. Roth

Abstract

The aging process is characterized by an altered ability to regulate various physiological functions (Shock, 1962; Roth, 1979; Masoro, 1981). Generally, such control is exerted by certain external factors such as nutrition, temperature, stress, and others, working through internal mechanisms involving hormones and neurotransmitters (Aldelman and Roth, 1982).

Keywords

Estrogen Receptor Estrogen Action Estrogenic Stimulation Cytoplasmic Receptor Receptor Loss 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adelman, R. C., 1971, Age-dependent effects on enzyme induction — a biochemical expression of aging, Exp. Gerontol. 6:49.CrossRefGoogle Scholar
  2. Adelman, R. C., and Roth, G. S. (eds.), 1982, Endocrine and Neuroendocrine Mechanisms of Aging, CRC Press, Boca Raton, Florida.Google Scholar
  3. Adelman, R. C., Stein, G., Roth, G. S., and Englander, D., 1972, Age-dependent regulation of mammalian DNA synthesis and cell proliferation in vivo, Mech. Ageing Dev. 1:49.CrossRefGoogle Scholar
  4. Ariz, B., and Knowler, J. T., 1980, The direction of messenger ribonucleic acid sequences in heterogeneous nuclear ribonucleic acid fractions of the estrogen-stimulated rat uterus, Biochem. J. 187:265.Google Scholar
  5. Arnaud, M., Beziat, Y., Guilleux, J. C., Hough, A., Hough, D., and Mousseron-Canet, M., 1971, Les recepteurs de l’oestradiol dans l’uterus de genisse stimulation de la biosynthese de RNA in vitro, Biochem. Biophys. Acta 232:117.PubMedGoogle Scholar
  6. Belisle, S., and Beaudry, C., 1982, Endocrine aging in CBA mice. Characterization of uterine cytosolic and nuclear sex steriod receptors, Exp. Gerontol. 17:417.PubMedCrossRefGoogle Scholar
  7. Belisle, S., and Lehoux, J-G., 1982, Endocrine aging in C57BL mice — II. Dynamics of estrogen receptors in the hypothalamic-pituitary axis, J. Steroid Biochem. 18:737.CrossRefGoogle Scholar
  8. Benz, E. W., Getz, M. J., Wells, D. J., and Moses, H. J., 1977, Nuclear RNA accumulation in cultured AKR mouse embryo cells stimulated to proliferate, Exp. Cell Res. 108:157.PubMedCrossRefGoogle Scholar
  9. Bolla, R., and Denckla, W. D., 1979, Effect of hypothesectomy on liver nuclear ribonucleic acic synthesis in aging rats, Biochem. J. 184:669.PubMedGoogle Scholar
  10. Borthwick, N. M., and Smellie, R. M. S. 1975, The effects of oestradiol-17β on ribonucleic acid polymerases of immature rabbit uterus, Biochem. J. 147:91.PubMedGoogle Scholar
  11. Burton, K., 1956, A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of DNA, Biochem. J. 62:315.PubMedGoogle Scholar
  12. Castle, T., Katz, A., and Richardson, A., 1978. Comparison of RNA synthesis by liver nuclei from rats of various ages, Mech. Ageing Dev. 9:383.CrossRefGoogle Scholar
  13. Chang, W-C., Hoopes, M. T., and Roth, G. S., 1981, Biosynthetic rats of proteins having the characteristics of glucocorticoid receptors in adipocytes of mature and senescent rats, J. Gerontol. 36:386.PubMedGoogle Scholar
  14. Chuknyiska, R. S., Haji, M., Foote, R. H., and Roth, G. S., 1984, Effect of in vivo estradiol administration on availability of rat uterine nuclear acceptor sites measured in vitro, Endocrinology 115:836.PubMedCrossRefGoogle Scholar
  15. Chuknyiska, R. S., Haji, M., Foote, R. H., and Roth, G. S., 1985, Age-associated changes in nuclear binding of rat uterine estradiol receptor complexes, Endocrinology 116:547.PubMedCrossRefGoogle Scholar
  16. Cohen, M. L., and Berkowitz, B. A., 1976, Vascular contraction. Effect of age and extracellular calcium, Blood Vessels 67:139.Google Scholar
  17. Cuatrecases, P., 1974, Membrane receptors, Annu. Rev. Biochem. 43:169.CrossRefGoogle Scholar
  18. Cutler, R. G., 1978, Alterations with age in the informational storage and flow systems of the mammalian cell, in: Genetic Effects on Aging (D. Bergsma and D. H. Harrison, eds.), Alan R. Liss, New York, pp. 463–498.Google Scholar
  19. Gee, M. V., Baum, B. J., and Roth, G. S., 1983, Stimulation of parotid cell glucose oxidation; Role of alpha-adrenergic receptors and calcium mobilization, Biochem. Pharmacol. 32:335.CrossRefGoogle Scholar
  20. Gesell, M. S., and Roth, G. S., 1981, Decrease in rate uterine estrogen receptors during aging: Physio-and immuno-chemical properties, Endocrinology 109:1502.PubMedCrossRefGoogle Scholar
  21. Glaser, S. R., Chytil, F., and Speisberg, T. C., 1972, Early effects of oestradiol-17β on the chromatin and activity of deoxyribonucleic acid-dependent ribonucleic acic polymerases (I and II) of the rat uterus, Biochem. J. 130:947.Google Scholar
  22. Greene, G. L., Close, L. E., Fleming, H., DeSombre, E. R., and Jensen, E. V., 1977, Antibodies to estrogen receptor: immunochemical similarity of estrophilin from various mammalian species, Proc. Natl. Acad. Sci. U.S.A. 74:3681.PubMedCrossRefGoogle Scholar
  23. Gregerman, R. I., and Bierman, E. L., 1981, Aging and hormones, in: Textbook of Endocrinology (R. H. Williams, ed.), Saunders, Philadelphia, pp. 1192–1212.Google Scholar
  24. Guarnieri, T., Filburn, C. R., Zitnik, G., Roth, G. S., and Lakatta, E. G., 1980, Contractile and biochemical correlates of β-adrenergic stimulation of the aged heart, Am. J. Physiol. 239:H501.PubMedGoogle Scholar
  25. Haji, M., and Roth, G. S., 1984, Impaired estrogen stimulation of RNA polymerase II activity in uterine nuclei of senescent rats, Mech. Ageing Dev. 25:141.PubMedCrossRefGoogle Scholar
  26. Haji, M., Chuknyiska, R. S., and Roth, G. S., 1985, Isolated uterine nuclei and cytosol receptors of aged rats exhibit impaired estrogenic stimulation of RNA polymerase II, Proc. Natl. Acad. Sci. U.S.A. 81:7481.CrossRefGoogle Scholar
  27. Henry, J. M., and Roth, G. S., 1985, Effect of aging on recovery of striatal dopamine receptors following N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) blockade, Life Sci. 35:899.CrossRefGoogle Scholar
  28. Hess, G. D., and Roth, G. S. (eds.), 1984, Receptors and Aging, in: Aging and Cell Functions (J. E. Johnson, ed.), Plenum Press, New York, pp. 149–185.Google Scholar
  29. Hewish, D. R., and Burgoyne, L. A., 1973, The calcium dependent endonuclease activity of isolated nuclear preparations, relationships between its occurrence and the occurrence of other classes of enzymes found in nuclear preparations, Biochem. Biophys. Res. Comm. 53:475.CrossRefGoogle Scholar
  30. Holinka, C. F., Nelson, J. F., and Finch, C. E., 1975, Effect of estrogen treatment on estradiol binding capacity in uteri of aged rats, Gerontologist 15:30.Google Scholar
  31. Hseueh, A. J. W., Erickson, G. F., and Lu, K. H., 1979, Changes in uterine estrogen receptor and morphology in aging female rats, Biol. Reprod. 21:793.CrossRefGoogle Scholar
  32. Huang, H. H., Steger, R. W., Bruni, J., and Meites, J., 1978, Changes in patterns of sex steroid and gonadotropin secretion in female rats, Endocrinology 103:1855.PubMedCrossRefGoogle Scholar
  33. Ito, H., Baum, B. J., Uchida, T., Hoopes, M. T., Bodner, L., and Roth, G. S., 1982, Diminished alpha adrenergic responsiveness in rat parotid acinar cells with normal receptor characteristics, J. Biol. Chem. 246:9532.Google Scholar
  34. Jensen, E. V., 1980, Monoclonal antibodies as probes for estrogen receptor structure, 3rd Intl. Colloq. on Physiol and Chemical Information Transfer in the Regulation of Reproduction and Aging, Varna, Bulgaria, p. 47.Google Scholar
  35. Jiang, M. J., and Peng, M. T., 1981, Cytoplasmic and nuclear binding of estradiol in the brain and pituitary of old female rats, Gerontology 27:51.PubMedCrossRefGoogle Scholar
  36. Joseph, J. A., Filburn, C. R., and Roth, G. S., 1981, Development of dopamine receptor denervation supersensitiviey in the neostriatum of the senescent rat, Life Sci. 29:575.PubMedCrossRefGoogle Scholar
  37. King, R. J. B., and Mainwaring, W. I. P. (eds.), 1974, Steroid-Cell Interactions, University Park Press, Baltimore.Google Scholar
  38. Knowler, J. T., and Smellie, R. M. S., 1973, The oestrogen-stimulated synthesis of heterogeneous nuclear ribonucleic acid in the uterus of immature rats, Biochem. J. 131:689.PubMedGoogle Scholar
  39. Kon, O. L., and Spelsberg, T. C., 1982, Nuclear binding of estrogen-receptor complex: Receptor-specific nuclear acceptor sites, Endocrinology 111:1925.PubMedCrossRefGoogle Scholar
  40. Labarca, C., and Paigen, K., 1980, A simple, rapid and sensitive DNA assay procedure, Anal. Biochem. 102:344.PubMedCrossRefGoogle Scholar
  41. Larson, L. L., Spilman, C. H., and Foote, R. H., 1972, Uterine uptake of progesterone and estradiol in young and aged rabbits, Proc. Soc. Exp. Biol. Med. 141:463.PubMedGoogle Scholar
  42. Lindell, T. J., 1980, Inhibition of mammalian RNA polymerase, in: Inhibitors of DNA and RNA Polymerases (P. S. Savin and R. C. Gallo, eds.), Pergamon Press, New York, pp. 111–137.Google Scholar
  43. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., 1951, Protein measurement with the Folin phenol reagent, J. Biol. Chem. 193:265.PubMedGoogle Scholar
  44. Masoro, E. J. (ed.), 1981, Handbook of Physiology in Aging, CRC Press, Boca Raton, Florida.Google Scholar
  45. Miller, J. K., and Bolla, R., 1981, Influence of steroid-hormone-receptor-protein complexes on initiation of ribonucleic acid synthesis in liver nuclei isolated from rats of various ages, Biochem. J. 196:373.PubMedGoogle Scholar
  46. Mohla, S., DeSombre, E. R., and Jensen, E. V., 1972, Tissue-specific stimulation of RNA synthesis by transformed estradiol-receptor complex, Biochem. Biophys. Res. Comm. 46:661.PubMedCrossRefGoogle Scholar
  47. Nelson, J. F., Holinka, C. F., and Finch, C. E., 1976, Age related changes in estradiol binding capacity of mouse uterine cytosol, Abstrs. 29th Ann. Mtg. of the Geront. Soc, p. 86.Google Scholar
  48. O’Malley, B. W., and Means, A. R. (eds.), 1978, Receptors for Reproductive Hormones, Plenum Press, New York.Google Scholar
  49. Orida, N., and Feldman, J. D., 1982, Age related deficiency in calcium uptake by mast cells, Fed. Proc. 41:822.Google Scholar
  50. Pavlik, E. J., and Coulson, P. B., 1976, Modulation of estrogen receptors in four different target tissues: Different effects of estrogen vs. progesterone, J. Steroid Biochem. 7:1.CrossRefGoogle Scholar
  51. Peng, M. T., and Peng, Y. M., 1973, Changes in the uptake of tritiated estradiol in the hypothalamus and adenohypophesis of old female rats, Fertil. Steril. 24:534.PubMedGoogle Scholar
  52. Peterson, C., and Gibson, G. E., 1983, Amelioration of age-related neurochemical and behavioral deficits by 3, 4-diaminopyridine, Neurobiol. Aging 4:25.PubMedCrossRefGoogle Scholar
  53. Pitha, J., Hughes, B. A., Kusiak, J. W., Dax, E. M., and Baker, S. P., 1982, Regeneration of beta-adrenergic receptors in senescent rats; study using an irreversible antagonist, Proc. Natl. Acad. Sci. U.S.A. 26:4424.CrossRefGoogle Scholar
  54. Pradham, S. N., 1980, Central neurotransmitters and aging, Life Sci. 26:1843.CrossRefGoogle Scholar
  55. Roeder, R. G., and Rutter, W. J., 1970, Multiple ribonucleic acid polymerases and ribonucleic acic synthesis during sea urchin development, Biochemistry 9:2543.PubMedCrossRefGoogle Scholar
  56. Rosner, B. A. and Cristofalo, V.J., 1981, Charges in specific dexamethasone binding during aging in WI-38 cells, Endocrinology 108:1965.PubMedCrossRefGoogle Scholar
  57. Roth, G. S., 1975, Reduced glucocorticoid responsiveness and receptor concentration in splenic leukocytes of senescent rats, Biochem. Biophys. Acta 399:145.PubMedCrossRefGoogle Scholar
  58. Roth, G. S., 1979, Horome action during aging, alterations and mechanisms, Mech. Ageing Dev. 9:497.PubMedCrossRefGoogle Scholar
  59. Roth, G. S., and Hess, G. D., 1982, Changes in the mechanisms of hormone and neurotransmitter action during aging: Current status of the role of receptor and post-receptor alterations, Mech. Ageing Dev. 20:175.PubMedCrossRefGoogle Scholar
  60. Roth, G. S., and Livingston, J. N., 1976, Reductions in glucocorticoid inhibition of glucose oxidation and presumptive glucocorticoid receptor content in rat adiporytes during aging, Endocrinology 99:831.PubMedCrossRefGoogle Scholar
  61. Roth, G. S., Karoly, K., Britton, V. J., and Adelman., R. C., 1974, Age dependent regulation of isoproterenol-stimulated DNA synthesis in rat salivary gland in vivo, Exp. Gerontol. 9: 1PubMedCrossRefGoogle Scholar
  62. Saiduddin, S., and Zassenhaus, H. P., 1979, Estrus cycles, decidualization response and uterine estrogen and progesterone receptor in Fisher 344 virgin aging rats, Proc. Soc. Exp. Biol. Med. 161:119.PubMedGoogle Scholar
  63. Shock, N. W., 1962, The physiology of aging, Sei. Am. 29:100.Google Scholar
  64. Singhal, R. L., Valadares, H. R. E., and Ling, G. M., 1969, Estrogenic regulation of uterine carbohydrate metabolism during senescence, Am. J. Physiol. 217:793.PubMedGoogle Scholar
  65. Soriero, A. A., 1980, Autorodiagraphic study of the effect of estrogen on in vivo incorporation of 3H-uridine into uterine smooth muscle and stromal RNA in the aging ovariectomized mouse, J. Gerontol. 35:167.PubMedGoogle Scholar
  66. Soriero, A. A., and Talbert, G. B., 1975, The effect of estrogen on protein and RNA concentration and on de novo synthesis of RNA in the uterus of aging overiectomized mice, J. Gerontol. 30:264.PubMedGoogle Scholar
  67. Steger, R. W., Huang, H. H., and Meites, J., 1979, Relation of aging to hypothalamic LHRH content and serum gonadal steroids in female rats, Proc. Soc. Exp. Biol. Med. 161:251.PubMedGoogle Scholar
  68. Webster, R. A., and Hamilton, T. H., 1976, Comparative effects of estradiol 17-β and estriol on uterine RNA polymerases I, II, and III in vivo, Biochem. Biophys. Res. Comm. 69:737.PubMedCrossRefGoogle Scholar
  69. Woll, W. W., Duffy, J. J., Giese, N. A., and Lindeil, T. J., 1981, Nuclear isolation by a modified method of Hewish and Burgoyne: Implication for the study of nuclear enxymology, Life Sci. 29:2709.PubMedCrossRefGoogle Scholar
  70. Zava, D. T., Harrington, N. Y., and McGuire, W. L., 1976, Nuclear estradiol receptor in the adult rat uterus: A new exchange essay, Biochemistry 15:4292.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • George S. Roth
    • 1
  1. 1.Molecular Physiology and Genetics Section, Gerontology Research Center, National Institute on Aging, National Institutes of HealthBaltimore City HospitalsBaltimoreUSA

Personalised recommendations