Methodological Issues in Clinical Research on the Aging Reproductive System
Aging of the reproductive system in both men and women results in symptoms that frequently require physician assistance, and changes in sexual function with advancing age represent a “hidden” concern of many older patients. Physiologic studies of aging including studies of reproductive aging require special attention to subject selection, characterization, and study design (Rowe, 1977). Failure to consider these factors explains much of the inconsistency in the literature, and careful adherence to study design and subject selection will lead to clarification of the mechanisms accounting for reproductive aging.
KeywordsPlasma Testosterone Subject Selection Reproductive Physiology Reproductive Aging Pulsatile Secretion
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