Methodological Issues in Clinical Research on the Aging Reproductive System

  • Kenneth L. Minaker
  • John W. Rowe


Aging of the reproductive system in both men and women results in symptoms that frequently require physician assistance, and changes in sexual function with advancing age represent a “hidden” concern of many older patients. Physiologic studies of aging including studies of reproductive aging require special attention to subject selection, characterization, and study design (Rowe, 1977). Failure to consider these factors explains much of the inconsistency in the literature, and careful adherence to study design and subject selection will lead to clarification of the mechanisms accounting for reproductive aging.


Plasma Testosterone Subject Selection Reproductive Physiology Reproductive Aging Pulsatile Secretion 
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  1. Atkinson, J. H., and Schuckit, M. A., Alcoholism and over-the-counter and prescription drug misuse in the elderly, in: Annual Review of Gerontology and Geriatrics (C. Eisdorfer, ed.), Springer, New York, pp. 255–284.Google Scholar
  2. Borkan, G. A., Hults, D. E., Gerzof, S. G., Robbins, A. H., Silbert, C. A., 1984, Age changes in body composition revealed by computed tomography, J. Gerontol. 38(6):673–677.Google Scholar
  3. Bremner, W. J., Vitiello, M. V., and Prinz, P, N., 1983, Loss of circadian rhythmicity in blood testosterone levels with aging in normal men, J. Clin. Endocrinol. Metab. 56(6):1278–1281.PubMedCrossRefGoogle Scholar
  4. Elahi, V. K., Elahi, D., Andres, R., Tobin, J. D., Butler, M. S., and Noms, A. H., 1983, A longitudinal study of nutritional intake in men, J. Gerontol. 38(2): 162–180.PubMedGoogle Scholar
  5. George, L. K., and Weiler, S. J., 1981, Sexuality in middle and late life. The effects of age, cohort, and gender, Arch. Gen. Psychiatry 38(8):919–923.PubMedCrossRefGoogle Scholar
  6. Gordon, G. G., Altman, K., Southern, A. L., Rubin, E., and Lieber, G. S., 1976, Effect of alcohol on sex hormone metabolism in normal men, N. Engl. J. Med. 295:793.PubMedCrossRefGoogle Scholar
  7. Gordon, T., and Shurtleff, D., 1973, Means at each examination and interexamination variation of specified characteristics: Framingham study, exam 1 to exam 10, The Framingham study: An epidemiologic investigation of cardiovascular disease (DHEW Publication No. NIH 74-478) (W. B. Kannel, T. Gordon, eds.), Washington, D.C., U.S. Government Printing Office.Google Scholar
  8. Grimley Evans, J., 1981, The biology of human aging, in: Recent Advances in Medicine (A. M. Dawson, N. Compston, and G. M. Besser, eds.), Churchill Livingston, London, pp. 17–38.Google Scholar
  9. Grimley Evans, J., 1984, Prevention of age-associated loss of autonomy: Epidemiologic approaches, J. Chronic Dis. 37(5):353–363.PubMedCrossRefGoogle Scholar
  10. Judd, H. D., Lucas, W. E., and Yen, S. S. C., 1976, 17 beta estradiol and estrone levels in postmenopausal women with and without endometrial cancer, J. Clin. EndocrinoL Metab. 43:272–278.PubMedCrossRefGoogle Scholar
  11. Kley, H. K., Nieschlag, E., Bidlingmaier, F., and Kruskemper, H. L., 1974, Possible age dependent influence of estrogens on the binding of testosterone in plasma of adult men, Horm. Metab. Res. 6:213–215.PubMedCrossRefGoogle Scholar
  12. Minaker, K. L., Rowe, J. W., Young, J. B., Pallotta, J., Landsberg, L., 1982, Effect of age on insulin stimulation of sympathetic nervous system activity in man, Metabolism 31:1181–1184.PubMedCrossRefGoogle Scholar
  13. Minaker, K. L., Meneilly, G. S., and Rowe, J. W., 1985, Endocrine systems, in: Handbook of the Biology of Aging, 2nd edition (C. Finch and E. Schneider, eds.), Van Nostrand Reinhold, New York, pp. 433–456.Google Scholar
  14. Nieschlag, E., Lammers, U., Freischem, C. W., Langer, K., Wickings, E. J., 1982, Reproductive function in young fathers and grandfathers, J. Clin. EndocrinoL Metab. 55(4):676–681.PubMedCrossRefGoogle Scholar
  15. Rossman, I., 1977, Anatomic and body composition changes with aging, in: Handbook of the Biology of Aging (C. Finch and L. Hayflick, eds.), Van Nostrand Reinhold, New York, pp. 189–221.Google Scholar
  16. Rowe, J. W., 1977, Clinical research on aging: Strategies and directions, N. Engl. J. Med. 297:1332–1336.PubMedCrossRefGoogle Scholar
  17. Rowe, J. W., and Minaker, K. L., 1985, Geriatric medicine, in: Handbook of the Biology of Aging, 2nd edition (C. Finch and E. Schneider, eds.), Van Nostrand Reinhold, New York pp. 932–959.Google Scholar
  18. Rowe, J. W., Minaker, K. L., Pallotta, J., and Flier, J. S., 1983, Characterization of the insulin resistance of aging, J. Clin. Invest. 71:1581–1587.PubMedCrossRefGoogle Scholar
  19. Rudman, D. D., and Girolamo, M., 1971, Effects of adrenal cortical steroids on lipid metabolism, in: The Human Adrenal Cortex (N. P. Christy, ed.), Harper and Row, New York, pp. 241–256.Google Scholar
  20. Saar, N., and Gordon, R. D., 1979, Variability of plasma catecholamine levels: age, duration of posture and time of day. Br. J. Clin. Pharmacol. 8:353–358.PubMedGoogle Scholar
  21. Shock, N., 1979, Systems physiology and aging, Fed. Proc. Fed. Am. Soc. Exp. Biol. 38:161–162.Google Scholar
  22. Slag, M. F., Morley, J. E., Elson, M. K., Trence, D. L., Nelson, C. V., Nelson, A. E., Kinlow, W. B., Beyer, H. S., Nuttall, F. Q., Shafer, and R. B., 1983, Impotence in medical clinic outpatients, JAMA 249(13): 1736–1740.PubMedCrossRefGoogle Scholar
  23. Sparrow, D., Bosse, R., and Rowe, J. W., 1980, The influence of age, alcohol consumption, and body build on gonadal function in men, J. Clin. Endocrinol. Metab. 51(3):508–512.PubMedCrossRefGoogle Scholar
  24. Swerdloff, R. S., and Heber, D., 1982, Effects of aging on male reproductive function, in: Endocrine Aspects of Aging (S. G. Korenman, ed.), Elsevier Biomedical, New York, pp. 119–136.Google Scholar
  25. Verwoerdt, A., Pfeiffer, E., and Wang, H. S., 1969, Sexual behavior in senescence II. Patterns of sexual activity and interest, Geriatrics 24:137–154.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Kenneth L. Minaker
    • 1
    • 2
  • John W. Rowe
    • 1
    • 2
  1. 1.Division on Aging, Harvard Medical School; Gerontology Division, Joint Department of MedicineBeth Israel and Brigham and Women’s HospitalsBostonUSA
  2. 2.Geriatric Research Education Clinical CenterWest Roxbury/Brockton Veterans Administration Medical CenterWest RoxburyUSA

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