Estrogen Deprivation

The Physiology, Pathophysiology, and Informed Management of Female Menopause or Castration
  • Nathan Kase


As a woman progresses through the fifth decade of life, the timing and function of the menstrual cycle change. The residual few thousand follicle units remaining in the ovaries at this age apparently are less sensitive to gonadotropin stimulation. This notion is supported by the progressive increase in follicle-stimulating hormone (FSH) and the reduced estrogen concentrations characteristic of the premenopause (Sherman et al., 1976). Limited follicle maturation leads either to decreased cycle interval (shortened follicle maturation phase at first, followed by an inadequate luteal phase) or to variable lapses of cyclicity (oli-goanovulation) with oligomenorrhea.


Breast Cancer Postmenopausal Woman Endometrial Cancer Luteinizing Hormone Estrogen Therapy 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Nathan Kase
    • 1
  1. 1.Department of Obstetrics, Gynecology, and Reproductive SciencesMount Sinai Medical CenterNew YorkUSA

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