Animal Models for the Human Menopause

  • Caleb E. Finch
  • Roger G. Gosden


This review emphasizes phenomena associated with reproductive aging changes in the human female that also occur in laboratory models. The decrease and loss of fertility during midlife is a universal characteristic of aging in the human female, as well as in many shorter-lived mammalian species (Finch, 1976; Harman and Talbert, 1985). Although it is often thought that reproductive aging in female laboratory rodents (Meites, 1982) might be a fundamentally different neuroendocrine process than reproductive aging in women (Guyton, 1981), recent studies suggest that many mammals share similar phenomena of reproductive senescence, in which ovarian aging changes play a key role. We refer to more comprehensive reviews where possible: see Gosden (1985), Krohn (1962), Finch et al. (1980, 1984), Meites (1982), Nelson and Felicio (1985), and Wise (1983). For general information on animal models of aging, see Gibson et al. (1979) and Anonymous (1981).


Luteinizing Hormone Estrous Cycle Primordial Follicle Premature Ovarian Failure Luteinizing Hormone Surge 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Caleb E. Finch
    • 1
  • Roger G. Gosden
    • 2
  1. 1.Department of Biological Sciences, Andrus Gerontology CenterUniversity of Southern CaliforniaLos AngelesUSA
  2. 2.Department of PhysiologyUniversity Medical SchoolEdinburghUK

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