Recent work reported in this volume supports the concept that many physiological and metabolic events are compartmented in different regions of the liver lobule. New insights into the structure and regulation of metabolism in the liver are presented. Chapters in this volume have illustrated state of the art methodology being employed to describe the nature of the biochemical microheterogeneity of the liver lobule. Mechanisms underlying the development of this microheterogeneity and its physiological significance are beginning to be studied with methods presented above. Challenges for the future involve refinement of these methodologies to gather more descriptive information as well as the design of meaningful experiments to better understand the role of microheterogeneity in normal hepatic function as well as derangements which occur with pathological states.
KeywordsLiver Lobule Meaningful Experiment Normal Hepatic Function Retrograde Direction Enzyme Distribution
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