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Biotransformation and Zonal Toxicity

  • Chapter
Regulation of Hepatic Metabolism

Abstract

Hepatotoxins are ubiquitous in nature. Chemical injury to the liver is dependent on the nature of the hepatotoxic agent and the circumstances of exposure (for a comprehensive review, see Zimmerman1). Products of plant, fungal, and bacterial metabolism, minerals,2–4 chemicals and pharmaceuticals, industrial byproducts, and waste materials can damage the liver.5 The types of hepatic injury that result from exposure to hepatotoxins are quite diverse. Some agents cause necrosis, fat accumulation, cirrhosis, or carcinoma,2 while others interfere with bile secretion, cause jaundice, and produce little or no injury to hepatocytes.2,5

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Authors and Affiliations

  1. Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, 27514, USA

    Ronald G. Thurman

  2. Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland, 21201, USA

    Frederick C. Kauffman

  3. The Toxicology Center, Department of Pharmacology, The University of Iowa College of Medicine, Iowa City, Iowa, 52242, USA

    Jeffrey Baron

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  1. Ronald G. Thurman
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  2. Frederick C. Kauffman
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  3. Jeffrey Baron
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Editors and Affiliations

  1. Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, 27514, USA

    Ronald G. Thurman

  2. Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland, 21202, USA

    Frederick C. Kauffman

  3. Georg-August Universität, Göttingen, Federal Republic of Germany

    Kurt Jungermann

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Thurman, R.G., Kauffman, F.C., Baron, J. (1986). Biotransformation and Zonal Toxicity. In: Thurman, R.G., Kauffman, F.C., Jungermann, K. (eds) Regulation of Hepatic Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5041-5_13

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