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Lobular Oxygen Gradients: Possible Role in Alcohol-Induced Hepatotoxicity

  • Ronald G. Thurman
  • Sungchul Ji
  • John J. Lemasters

Abstract

Alcoholic liver disease is a major health problem, and specific therapies are lacking because we still do not understand how alcohol causes liver damage. The purpose of this chapter is to evaluate the evidence for and against the hypothesis that hypoxia is involved in this disease. We shall review hepatic oxygen uptake, ethanol metabolism and adaptations, and hypoxic tissue damage in general briefly.

Keywords

Oxygen Uptake Alcohol Dehydrogenase Alcoholic Liver Disease Liver Lobule Perfuse Liver 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Ronald G. Thurman
    • 1
  • Sungchul Ji
    • 1
  • John J. Lemasters
    • 2
  1. 1.Department of PharmacologySchool of Medicine, University of North CarolinaChapel HillUSA
  2. 2.Department of AnatomySchool of Medicine, University of North CarolinaChapel HillUSA

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