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Liver Structure and Innervation

  • Dieter Sasse

Abstract

The problems one encounters in any attempt to describe the architecture of the liver date back to the beginnings of light microscopy itself. For most other organs, it is not very difficult to establish conformity between the structural and functional units, and in such cases the proposed nomenclature makes use of the suffix “-on.” Thus, the nephron is the structural and functional unit of the kidney, the neuron of nervous tissue, the chondron of cartilage, and so on. The term “hepaton” was used years ago, but it has never really been accepted because the structural units are difficult to recognize and because the liver has two quite separate functions. As an organ of excretion, it is connected by the bile duct to the gut, for which it serves as a gland comparable to the pancreas, whereas its type of microcirculation is similar to that of an endocrine organ that also acts in a heterotopic position. This chapter demonstrates that despite our increased knowledge, fundamental problems persist when hepatic structures are described in terms of their functional aspects.

Keywords

Kupffer Cell Liver Lobule Binucleate Cell Celiac Plexus Septum Transversum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Daoust, R., 1958, The cell population of liver tissue and the cytological reference bases, Am. Inst. Biol. Sci. Publ. 4: 3–10.Google Scholar
  2. 2.
    Elias, H., 1955, Liver morphology, Biol. Rev. 30: 263–310.CrossRefGoogle Scholar
  3. 3.
    Jacobj, W., 1925, Über das rhythmische Wachstum der Zellen durch Verdoppelung ihres Volumens, Roux Arch. 106: 124–192.CrossRefGoogle Scholar
  4. 4.
    Carriere, R., 1969, The growth of liver parenchymal nuclei and its endocrine regulation, Int. Rev. Cytol. 25: 201–277.PubMedCrossRefGoogle Scholar
  5. 5.
    Amano, M., 1967, Metabolism of RNA in the liver cells of the rat. I. Isolation and chemical composition of nucleus, nucleolus, chromatin, nuclear sap and cytoplasm, Exp. Cell Res. 46: 169–179.PubMedCrossRefGoogle Scholar
  6. 6.
    Münzer, F. T., 1923, Über die Zweikernigkeit der Leberzellen, Arch. Mikrosk. Anat. 98: 249–282.Google Scholar
  7. 7.
    Alfert, M., and Geschwind, J. J., 1958, Development of polysomaty in the rat liver, Exp. Cell Res. 15: 230–232.PubMedCrossRefGoogle Scholar
  8. 8.
    Nadal, D., and Zajdela, F., 1966, Polyploïdie somatique dans le foie de rat. I. Le rôle des cellules binuclées dans la génèse des cellules polyploïdes, Exp. Cell Res. 42: 99–116.PubMedCrossRefGoogle Scholar
  9. 9.
    James, J., Tas, J., Bosch, K. S., de Meere, A. J. P., and Schuyt, H. C., 1979, Growth patterns of rat hepatocytes during postnatal development, Eur. J. Cell Biol. 19: 222–226.PubMedGoogle Scholar
  10. 10.
    Geller, S., 1965, Intralobular distribution of polyploid cells in rat liver, Anat.Rec. 151: 352–353.Google Scholar
  11. 11.
    Van Noorden, C. J. F., Bhattacharya, R. D., and Fronik, G., 1984, Glucose-6-phosphate dehydrogenase activity in individual rat hepatocytes of different ploidy classes. II. Day time dependent variations, Chronobiologia (in press).Google Scholar
  12. 12.
    Brodsky, W. Y., and Uryvaeva, J. V., 1977, Cell polyploidy: Its relation to tissue growth and function, Int. Rev. Cytol. 50: 275–332.PubMedCrossRefGoogle Scholar
  13. 13.
    Bucher, N. L. R., 1963, Regeneration of mammalian liver, Int. Rev. Cytol. 15: 245–300.PubMedCrossRefGoogle Scholar
  14. 14.
    Denk, H., and Franke, W. W., 1982, Cytoskeletal filaments, in: The Liver: Biology and Pathobiology (J. M. Arias, H. Popper, D. Schachter, and D. A. Shafritz, eds.), Raven Press, New York.Google Scholar
  15. 15.
    Loud, A. V., 1968, A quantitative stereological description of the ultrastructure of normal rat liver parenchymal cells, J. Cell Biol. 37: 27–46.PubMedCrossRefGoogle Scholar
  16. 16.
    Novikoff, A. B., and Shin, W. Y., 1978, Endoplasmic reticulum and autophagy in rat hepa-tocytes, Proc. Natl. Acad. Sci. U.S.A. 75: 5039–5042.PubMedCrossRefGoogle Scholar
  17. 17.
    Novikoff, A. B., and Novikoff, P. M., 1977, Cytochemical contributions to differentiating GERL from the Golgi apparatus, Histochem. J. 9: 525–551.PubMedCrossRefGoogle Scholar
  18. 18.
    Hruban, Z., and Rechcigl, M., 1969, Microbodies and Related Particles, Academic Press, New York.Google Scholar
  19. 19.
    Jahn, W., 1980, The cytoskeleton of rat liver parenchymal cells, Naturwissenschaften 67: 568.PubMedCrossRefGoogle Scholar
  20. 20.
    Riede, U. N., and Sasse, D., 1981, Quantitative topography of organelles in the liver: A combined histochemical and morphometric analysis, Cell Tissue Res. 221: 209–220.PubMedCrossRefGoogle Scholar
  21. 21.
    Blouin, A., 1977, Morphometry of liver sinusoidal cells, in: Kupffer Cells and Other Liver Sinusoidal Cells (E. Wisse and D. L. Knook, eds.), pp. 61–71, Elsevier/North-Holland, Amsterdam.Google Scholar
  22. 22.
    Wisse, E., De Zanger, R., and Jacobs, R., 1982, Lobular gradients in endothelial fenestrae and sinusoidal diameter favour centrolobular exchange processes: A scanning EM study, in: Sinusoidal Liver Cells (D. L. Knook and E. Wisse, eds.), pp. 61–67, Elsevier, Amsterdam.Google Scholar
  23. 23.
    Gumucio, J. J., and Miller, D. L., 1982, Liver cell heterogeneity, in: The Liver: Biology and Pathobiology (J. M. Arias, H. Popper, D. Schachter, and D. A. Shafritz, eds.), Raven Press, New York.Google Scholar
  24. 24.
    Wisse, E., 1977, Ultrastructure and function of Kupffer cells and other sinusoidal cells in the liver, in: Kupffer Cells and Other Liver Sinusoidal Cells (E. Wisse and D. L. Knook, eds.), pp. 33–60, Elsevier/North-Holland, Amsterdam.Google Scholar
  25. 25.
    Hosemann, W., Teutsch, H. F., and Sasse, D., 1979, Identification of G6PDH active sinusoidal cells as Kupffer cells in the rat liver, Cell Tissue Res. 196: 237–247.PubMedCrossRefGoogle Scholar
  26. 26.
    Ito, T., and Nemoto, M., 1952, Über die Kupfferschen Sternzellen und die “Fettspeicherungs-zellen” (“fat storing cells”) in der Blutkapillaren wand der menschlichen Leber, Okajimas Folia Anat. Jpn. 24: 243–258.PubMedGoogle Scholar
  27. 27.
    Bronfenmajer, S., Schaffner, F., and Popper, H., 1966, Fat storing cells (lipocytes) in human liver, Arch. Pathol. 82: 447–453.PubMedGoogle Scholar
  28. 28.
    MacGee, J. O. D., and Patrick, R. S., 1972, The role of perisinusoidal cells in hepatic fibro-genesis: An electron microscopic study of acute carbon tetrachloride liver injury, Lab. Invest. 26: 429–440.Google Scholar
  29. 29.
    Wisse, E., Noordende, J. M., Van’t Meulen, J., and Van der Daems, W. T. H., 1976, The pit cell: Description of a new type of cell occurring in rat liver sinusoids and peripheral blood, Cell Tissue Res. 173: 423–435.PubMedCrossRefGoogle Scholar
  30. 30.
    Kaneda, K., and Wake, K., 1983, Distribution and morphological characteristics of the pit cells in the liver of the rat. Cell Tissue Res. 233: 485–505.PubMedCrossRefGoogle Scholar
  31. 31.
    Wepfer, H. E., 1664, De dubiis anatomicis, epistula ad Jacob. Hen. Paulum, Nürnberg.Google Scholar
  32. 32.
    Malpighi, M., 1666, De viscerum structura exercitatio anatomica, London.Google Scholar
  33. 33.
    Kiernan, F., 1833, The anatomy and physiology of the liver, Philos. Trans. R. Soc. London, pp. 711-770.Google Scholar
  34. 34.
    Mall, F. P., 1906, A study of the structural unit of the liver, Am. J. Anat. 5: 227–308.CrossRefGoogle Scholar
  35. 35.
    Rappaport, A. M., Borowy, Z. J., Longheed, W. M., and Lotto, W. N., 1954, Subdivision of hexagonal liver lobules into a structural and functional unit: Role in hepatic physiology and pathology, Anat. Rec. 119: 11–34.PubMedCrossRefGoogle Scholar
  36. 36.
    Rappaport, A.M., 1976, The microcirculatory acinar concept of normal and pathological hepatic structure, Beitr. Pathol. 157: 215–243.PubMedCrossRefGoogle Scholar
  37. 37.
    Zeiger, K., 1952, Zur funktionellen Anatomie der Leber, Dtsch. Z. Verdau. Stoffwechselkr. Sonderbd. 22-31.Google Scholar
  38. 38.
    Jungermann, K., and Sasse, D., 1978, Heterogeneity of liver parenchymal cells, Trends Biochem. Sci. 3: 198–202.CrossRefGoogle Scholar
  39. 39.
    Matsumoto, T., Komori, R., Magara, T., Ui, T., Kawakami, M., Tokuda, T., Takasaki, S., Hayashi, H., Jo, K., Hano, H., Fujino, H., and Tanaka, H., 1979, A study on the normal structure of the human liver, with special reference to its angioarchitecture, Jikeikai Med. J. 26: 1–40.Google Scholar
  40. 40.
    Bloch, E. H., 1970, The determination of hepatic arterioles and the functional unit of the liver as determined by microscopy of the living organ, Ann. N. Y. Acad. Sci. 170: 78–87.CrossRefGoogle Scholar
  41. 41.
    Teutsch, H. F., 1981, Chemomorphology of liver parenchyma, Prog. Histochem. Cytochem. 14(3).Google Scholar
  42. 42.
    Riegele, L., 1928, Über das feinere Verhalten der Nerven in der Leber von Mensch und Säugetier, Z. Mikrosk.-Anat. Forsch. 14: 73–98.Google Scholar
  43. 43.
    Alexander, W. F., 1940, The innervation of the biliary system, J. Comp. Neurol. 72: 357–370.CrossRefGoogle Scholar
  44. 44.
    Stelmasiak, M., and Kurylcio, L., 1971, Nerwy watroby i drog zolciowych, Folia Morphol. (Warsaw) 30: 169–182.Google Scholar
  45. 45.
    Lautt, W. W., 1980, Hepatic nerves: A review of their functions and effects, Can. J. Physiol. Pharmacol. 58: 105–123.PubMedCrossRefGoogle Scholar
  46. 46.
    De Wulf, H., and Carton, H., 1981, Neural control of glycogen metabolism, in: Short-Term Regulation of Liver Metabolism (L. Hue and G. Van de Werve eds.), Elsevier/North-Holland, Amsterdam.Google Scholar
  47. 47.
    Russek, M., 1971, Hepatic receptors and the neurophysiological mechanisms controlling feeding behavior, in: Neuroscience Research (S. Ehrenpreis, ed.), pp. 213–282, Academic Press, New York.Google Scholar
  48. 48.
    Shimazu, T., 1981, Central nervous system regulation of liver and adipose tissue metabolism, Diabetologia 20 (Suppl.)343–356.PubMedCrossRefGoogle Scholar
  49. 49.
    Rogers, R. C., and Hermann, G. E., 1983, Central connections of the hepatic branch of the vagus nerve: A horseradish peroxidase histochemical study, J. Auton. Nerv. Syst. 7: 165–174.PubMedCrossRefGoogle Scholar
  50. 50.
    Ungvary, G., 1977, Functional Morphology of the Hepatic Vascular System, Adadémiai Kiadö, Budapest.Google Scholar
  51. 51.
    Tonelli, F., Amenta, F., Cavalotti, C., and Ferrante, F., 1981, Cholinergic nerves in the human liver, Histochem. J. 13: 419–424.PubMedCrossRefGoogle Scholar
  52. 52.
    De Luca, C., Cantagalli, A., De Angelis, E., and Amenta, F., 1982, Cholinergic nerves in the rat portal vein, Experientia 38: 397–398.PubMedCrossRefGoogle Scholar
  53. 53.
    Skaaring, P., and Bierring, F., 1977, Further evidence for the existence of intralobular nerves in the rat liver, Cell Tissue Res. 177: 287–290.PubMedCrossRefGoogle Scholar
  54. 54.
    Reilly, F. D., McCuskey, A. P., and McCuskey, R. S., 1978, Intrahepatic distribution of nerves in the rat, Anat. Rec. 191: 55–67.PubMedCrossRefGoogle Scholar
  55. 55.
    Ungváry, G., and Varga, B., 1971, Intralobular redistribution of tissue circulation in the canine liver. II. Effect of the stimulation on certain peripheral nerves, Acta Physiol. Acad. Sci. Hung. 40: 347–357.PubMedGoogle Scholar
  56. 56.
    Forssmann, W. G., and Ito, S., 1977, Hepatocyte innervation in primates, J. Cell Biol. 74: 299–313.PubMedCrossRefGoogle Scholar
  57. 57.
    Metz, W., and Forssmann, W. G., 1980, Innervation of the liver in guinea pig and rat, Anat. Embryol. 160: 239–252.PubMedCrossRefGoogle Scholar
  58. 58.
    Moghimzadeh, E., Nobin, A., and Rosengren, E., 1982, Adrenergic nerves and receptors in the liver, Brain Res. Bull. 9: 709–714.PubMedCrossRefGoogle Scholar
  59. 59.
    Yamada, E., 1965, Some observations on the nerve terminal on the liver parenchymal cell of the mouse as revealed by electron microscopy, Okajimas Folia Anat. Jpn. 40: 663–677.PubMedGoogle Scholar
  60. 60.
    Nobin, A., Baumgarten, H. G., Falck, F., Jngemansson, S., Moghimzadeh, E., and Rosengren, E., 1978, Organization of the sympathetic innervation in liver tissue from monkey and man, Cell Tissue Res. 195: 371–380.PubMedCrossRefGoogle Scholar
  61. 61.
    Wiener, J., Loud, A. V., Kimberg, D., and Spiro, D., 1968, A quantitative description of cortisone induced alteration in the ultrastructure of rat liver parenchymal cells, J. Cell Biol. 37: 41–62.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Dieter Sasse
    • 1
  1. 1.Institute of AnatomyUniversity of BaselBaselSwitzerland

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