Prevention of Tardive Dyskinesia

  • Edmond H. Pi
  • George M. Simpson


Neuroleptics produce many unwanted effects including extrapyramidal side effects. The latter usually occur early in treatment and are seen frequently in psychiatric practice. Recently, much attention has been given to the late-onset condition, tardive dyskinesia (TD). Despite the fact that this syndrome was described in the literature soon after the introduction of neuroleptics in the early 1950s (Schonecker, 1957: Sigwald et al., 1959), there is still wide disagreement among investigators regarding its prevalence (estimates have ranged from 0.5% to 56%). This reflects the need for a precise definition of TD (Simpson et al., 1982) and has hampered clinicians’ efforts to make an early diagnosis of TD. The availability of standardized, objectively defined rating scales (NIMH, 1975; Simpson et al.,1979) and other diagnostic devices represents a significant advance in clarifying these problems (Schooler and Kane, 1982). These developments provide clinicians with a useful tool to objectively document the evolution and severity of TD. This represents the first step toward the goal of preventing the debilitating and sometimes irreversible effects of this disorder.


Tardive Dyskinesia Fusaric Acid Extrapyramidal Side Effect Drug Holiday Fluphenazine Decanoate 
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Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Edmond H. Pi
    • 1
  • George M. Simpson
    • 2
  1. 1.Department of PsychiatryUniversity of Southern California School of MedicineLos AngelesUSA
  2. 2.Department of PsychiatryThe Medical College of PennsylvaniaPhiladelphiaUSA

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