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The Clinical Evaluation of Drug Therapy in Parkinsonism and Models of Dysfunction of Brain Dopamine Systems in Animals

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Book cover Movement Disorders

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Abstract

The observation by Ehringer and Hornykiewicz (1960) that patients who had died with Parkinson’s disease showed cellular degeneration of basal ganglia structures and a deficiency of dopamine (DA) within this area was a key link in the concept that a deficiency in a specific substance was intimately involved in the pathogenesis of a neurological disorder. The efficacy of levodopa treatment in Parkinson’s disease obviously reinforced this idea. At about the same time as these discoveries, both biochemical and histological techniques became available for researchers to examine brain catecholamine systems that appeared to be involved in neurological illnesses (Carlsson, 1959; Dahlström and Fuxe, 1964).

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Author notes

  1. J. R. Bianchine

    Present address: Medical Affairs, American Critical Care, McGaw Park, Illinois, 60085, USA

Authors and Affiliations

  1. Department of Pharmacology, College of Medicine, The Ohio State University, Columbus, Ohio, 43210, USA

    J. R. Bianchine, R. D. Schwartz & C. W. Richard III

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  1. J. R. Bianchine
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Editors and Affiliations

  1. Ensor Foundation Research Laboratory, William S. Hall Psychiatric Institute, Columbia, South Carolina, USA

    Nandkumar S. Shah Ph.D. (Director, Research Professor) (Director, Research Professor)

  2. Department of Neuropsychiatry and Behavioral Science, University of South Carolina School of Medicine, Columbia, South Carolina, USA

    Nandkumar S. Shah Ph.D. (Director, Research Professor) & Alexander G. Donald M.D. (Director, Professor and Chairman) (Director, Research Professor) &  (Director, Professor and Chairman)

  3. William S. Hall Psychiatric Institute, Columbia, South Carolina, USA

    Alexander G. Donald M.D. (Director, Professor and Chairman) (Director, Professor and Chairman)

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© 1986 Plenum Publishing Corporation

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Bianchine, J.R., Schwartz, R.D., Richard, C.W. (1986). The Clinical Evaluation of Drug Therapy in Parkinsonism and Models of Dysfunction of Brain Dopamine Systems in Animals. In: Shah, N.S., Donald, A.G. (eds) Movement Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5038-5_5

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  • DOI: https://doi.org/10.1007/978-1-4684-5038-5_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5040-8

  • Online ISBN: 978-1-4684-5038-5

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