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The Clinical Evaluation of Drug Therapy in Parkinsonism and Models of Dysfunction of Brain Dopamine Systems in Animals

A Review
  • J. R. Bianchine
  • R. D. Schwartz
  • C. W. RichardIII

Abstract

The observation by Ehringer and Hornykiewicz (1960) that patients who had died with Parkinson’s disease showed cellular degeneration of basal ganglia structures and a deficiency of dopamine (DA) within this area was a key link in the concept that a deficiency in a specific substance was intimately involved in the pathogenesis of a neurological disorder. The efficacy of levodopa treatment in Parkinson’s disease obviously reinforced this idea. At about the same time as these discoveries, both biochemical and histological techniques became available for researchers to examine brain catecholamine systems that appeared to be involved in neurological illnesses (Carlsson, 1959; Dahlström and Fuxe, 1964).

Keywords

Tardive Dyskinesia Squirrel Monkey Locomotor Behavior Parkinsonian Patient Dopaminergic Drug 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • J. R. Bianchine
    • 1
  • R. D. Schwartz
    • 1
  • C. W. RichardIII
    • 1
  1. 1.Department of Pharmacology, College of MedicineThe Ohio State UniversityColumbusUSA

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