Physiology and Pharmacology
  • Richard P. Newman
  • Donald B. Calne


Major advances have been made in the last two decades in understanding the biochemical pharmacology and pathophysiology of Parkinson’s disease. The value of levodopa as the mainstay for chronic therapy of parkinsonism is well established. Aspects of the cardinal features of parkinsonism, rigidity, tremor, and bradykinesia, have become better elucidated by physiological analysis. Recent insights into receptor mechanisms provide new approaches to pharmacotherapy.


Dopamine Receptor Essential Tremor Tardive Dyskinesia Prolactin Release Ergot Derivative 
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Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Richard P. Newman
    • 1
  • Donald B. Calne
    • 1
  1. 1.Experimental Therapeutics Branch, National Institute of Neurological and Communicative Disorders and StrokeNational Institutes of HealthBethesdaUSA

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