The adrenocorticosteroids drugs are an important group of therapeutic compounds used for a variety of clinical purposes. It is estimated that annually at least 5 million patients in the United States receive adrenocortical steroids. These agents are used in hormonal replacement therapy as well as for extension of their physiological actions. The adrenocorticosteroids are well recognized for the diversity of their actions underlying their extensive therapeutic use. It is the anti-inflammatory and immunosuppressive activity produced by these steroids that is widely sought for the palliative therapy of many clinical conditions. As would be expected of drugs that influence a multiplicity of tissues, the adrenocortical steroids produce a number of adverse effects. A well-founded appreciation for the pharmacological characteristics of these drugs provides the basis for the rational and safe use of this important group of drugs.
KeywordsAdrenal Gland Glucocorticoid Receptor Congenital Adrenal Hyperplasia Glucocorticoid Therapy Status Asthmaticus
Unable to display preview. Download preview PDF.
Physiology of the Adrenocorticosteroids
Pharmacology of the Adrenocorticosteroids
- Chamberlain, P., and Meyer, W. J., Management of pituitary-adrenal suppression secondary to corticosteroid therapy, Pediatrics 67:245, 1981.Google Scholar
- Fass, B., Glucocorticoid therapy for nonendocrine disorders: Withdrawal and coverage, Ped. Clin. N. Am. 26:251, 1979.Google Scholar
- Lagerquist, L. G., and Tyler, F. H., Diagnosis and treatment of disorders of the adrenal cortex, Pharmacol. Ther. 1:259, 1976.Google Scholar
- Quinn, S., and Snader, T. C., Corticosteroid therapy for septic shock: Review and analysis, Drug Intel Clin. Pharm. 14:247, 1980.Google Scholar
- Shapiro, G.G., Corticosteroids in the treatment of allergic disease — Principles and practice, Ped. Clin. N. Am. 30:955, 1983.Google Scholar
- Weintraub, M., and Bakst, A., Trilostane: A new inhibitor of adrenal cortical hormone synthesis, Hosp. Form. 20:1051–1054, 1985.Google Scholar