Progestins and Oral Contraceptives
Development and maintenance of the female reproductive system are dependent on the cyclical interaction between estrogens, primarily es-tradiol-17β, and progesterone. The principal target tissues for these steroid hormones include the uterus, vagina, fallopian tubes, and mammary glands, as well as the anterior pituitary and hypothalamus. Although estrogens are recognized as promoters of cellular proliferation, progestins are known to facilitate cellular differentiation. In addition, progesterone and related drugs exert significant antiestrogenic effects. It is the balance between estrogen and progesterone actions that regulates the state of the female reproductive system. Some of the therapeutically useful derivatives of progesterone share a structural similarity to androgens, and these agents in some instances also produce androgenic or antiandrogenic activity.
KeywordsProgesterone Receptor Luteinizing Hormone Oral Contraceptive Corpus Luteum Uterine Bleeding
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Physiology and Pharmacology of the Progestins
- Benagiano, G., Zulli, P., and Diczfalusy, E., Progestogens in therapy, Serono Symp. Ser. 3:1–270, 1983.Google Scholar
- Edgren, R. A., Progestagens, in: Clinical Use of Sex Steroids (J. R. Givens, ed.), pp. 1–29, Year Book Medical Publishers, Chicago, 1979.Google Scholar
- Horowitz, K. B., Wey, L. L., Sedlacek, S. M., and d’Arville, C. N., Progestin action and progesterone receptor structure in human breast cancer: A review, Recent Prog. Horm. Res. 41:249–317, 1985.Google Scholar
- Keenan, E. J., The physiological and pathophysiological significance of steroid hormone receptors, Gynecol. Obstet. 5:343, 1982.Google Scholar
- McGuire, W. L., and Clark, G. M., Role of progesterone receptors in breast cancer, J. Sem. Oncol. 12:12–16, 1985.Google Scholar
- Neumann, F., Progestogens: A short review, Postgrad. Med. J. (Suppl. 2) 54:11, 1978.Google Scholar