Androgenic and Anabolic Steroids
Androgens are steroid hormones that possess virilizing actions and, consequently, serve to stimulate differentiation and maintenance of the androgen-dependent tissues of the male reproductive system. These hormones also play an important role in facilitating protein synthesis in androgen-sensitive tissues such as skeletal muscle, bone, and the kidneys. Both the androgenic and anabolic actions of the androgens are exploited therapeutically. The principal clinical uses of the androgens include replacement therapy in hypogonadism and anabolic stimulation in states of negative nitrogen balance. Significant interest has also been devoted to the development of androgen antagonists. These compounds hold great potential usefulness in the management of prostatic hyperplasia and carcinoma. Both conditions represent abnormal growth patterns that often exhibit a significant degree of androgen dependence, which could be antagonized by antiandrogens.
KeywordsAndrogen Receptor Luteinizing Hormone Nuclear Matrix Anabolic Steroid Cyproterone Acetate
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Physiology of the Androgens
Pharmacology of the Androgens
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Pharmacology of Weak Androgens and Antiandrogens
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