Androgenic and Anabolic Steroids

  • John A. Thomas
  • Edward J. Keenan


Androgens are steroid hormones that possess virilizing actions and, consequently, serve to stimulate differentiation and maintenance of the androgen-dependent tissues of the male reproductive system. These hormones also play an important role in facilitating protein synthesis in androgen-sensitive tissues such as skeletal muscle, bone, and the kidneys. Both the androgenic and anabolic actions of the androgens are exploited therapeutically. The principal clinical uses of the androgens include replacement therapy in hypogonadism and anabolic stimulation in states of negative nitrogen balance. Significant interest has also been devoted to the development of androgen antagonists. These compounds hold great potential usefulness in the management of prostatic hyperplasia and carcinoma. Both conditions represent abnormal growth patterns that often exhibit a significant degree of androgen dependence, which could be antagonized by antiandrogens.


Androgen Receptor Luteinizing Hormone Nuclear Matrix Anabolic Steroid Cyproterone Acetate 
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Recommended Readings

Physiology of the Androgens

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Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • John A. Thomas
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
  • Edward J. Keenan
    • 7
    • 8
    • 9
    • 10
  1. 1.Corporate ResearchTravenol Laboratories, Inc.Round LakeUSA
  2. 2.Department of PharmacologyNorthwestern University School of MedicineChicagoUSA
  3. 3.Department of UrologyNorthwestern University School of MedicineChicagoUSA
  4. 4.Department of Pharmacology and ToxicologyWest Virginia School of MedicineMorgantownUSA
  5. 5.Department of PharmacologyUniversity of Illinois School of MedicineChicagoUSA
  6. 6.Department of PharmacologyRush-Presbyterian School of MedicineChicagoUSA
  7. 7.Hormone Receptor Laboratory, School of MedicineThe Oregon Health Sciences UniversityPortlandUSA
  8. 8.Department of Surgery, School of MedicineThe Oregon Health Sciences UniversityPortlandUSA
  9. 9.Department of Pharmacology, School of MedicineThe Oregon Health Sciences UniversityPortlandUSA
  10. 10.Department of Medicine (Medical Oncology), School of MedicineThe Oregon Health Sciences UniversityPortlandUSA

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