Selected Aspects of Enzyme Regulation in Parasites
Carbohydrate has been shown to be the major energy reserve in parasitic helminths. The details of carbohydrate degradation have been studied in a number of helminths (Bueding and Saz, 1968; Saz, 1970, 1971). It is clear from these studies that carbohydrate catabolism results in the production of acid end products which are persistent under either aerobic or anaerobic conditions. Carbohydrate catabolism in these helminths follows the conventional glycolytic sequence to phosphoenol-pyruvate (PEP) which may then be acted upon by pyruvate kinase (126.96.36.199, ATP: Pyruvate phosphotransferase) to yield pyruvate and subsequently, lactate and acetate, or by phosphoenolpyruvate carboxykinase (188.8.131.52, GTP: oxalacetate carboxylase) to yield oxaloacetate, malate, and ultimately succinate (Saz 1970, 1971).
KeywordsPyruvate Kinase Adult Worm Enzyme Regulation Hill Slope Parasitic Helminth
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