Diffraction Studies on Crystals of Ribosomal Particles
One of the most fascinating biochemical processes is the biosynthesis of protein molecules. This intricate and accurate process takes place in all organisms on their ribosomes in a similar manner. It involves specific interactions of the ribosomes with mRNAs, aminoacyl-tRNAs and a number of proteins such as initiation, elongation and termination factors. During this process the ribosomes dissociate into their two subunits which reassociate after the initiation process. Each of these subunits is a structurally independent distinct assembly of many proteins and several RNA chains.
KeywordsRibosomal Subunit Bacillus Stearothermophilus Large Ribosomal Subunit Interparticle Contact Hirano Body
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- 1.G. Chambliss, G. R. Craven, J. Davies, K. Davis, L. Kahan, and M. Nomura (eds), “Ribosomes: Structure, Function and Genetics,” University Park Press, Baltimore (1980).Google Scholar
- 11.T. Arad, K. Leonard, H. G. Wittmann, and A. Yonath, Two-dimensional crystalline sheets of Bacillus stearothermophilus 50S ribosomal particles, The EMBO J. 3:127–131 (1984).Google Scholar
- 13.A. Yonath, J. Müssig, B. Tesche, S. Lorenz, V. A. Erdmann, and H. G. Wittmann, Crystallization of the large ribosomal subunits from Bacillus stearothermophilus, Biochem. Internat. 1:428–453 (1980).Google Scholar
- 17.K. R. Leonard, T. Arad, B. Tesche, V. A. Erdmann, H. G. Wittmann, and A. Yonath, Crystallization, electron microscopy and three-dimensional reconstruction studies of ribosomal subunits, 10th Internatl. Congr. Electron Microscopy, Hamburg, Vol. 3:9–15 (1984).Google Scholar
- 22.A. Yonath, G. Khavitch, B. Tesche, J. Müssig, S. Lorenz, V. A. Erdmann, and H. G. Wittmann, The nucleation of crystals of the large ribosomal subunits from Bacillus stearothermophilus, Biochem. Internat. 5:629–636 (1982).Google Scholar