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Hydrodynamics, Thermodynamics and Scattering Properties: Nucleic Acids, Nucleosomes and Chromatin

  • Henryk Eisenberg
Part of the NATO ASI Series book series (NSSA, volume 98)

Abstract

Though the progress of both experimental and theoretical chemistry has been steady since the eighteenth century, it was only in our lifetime that the nature of the macromolecular state was clearly established. Until about fifty years ago it was generally believed that large, covalently bonded, well defined macromolecules do not exist, and only ill-defined colloidal structures and complexes are formed1. Thus DNA, known since 1869, was considered to be a colloidal aggregate of tetranucleotides of unknown structure and function2. Once the basic principle was recognized that various atoms (such as carbon, nitrogen, oxygen, phosphorous and others) can join to form long chains, the macromolecular state could be defined and studied. The very important functional properties of biological macromolecules were quickly recognized and the classical contribution of Watson and Crick3 provided the link between structure and function. Today we again stand at the threshold of a major revolution. We are witnessing the possibility to interfere with genetic, developmental and regulatory features of the biological machinery, in which macromolecules play a major role4.

Keywords

Core Particle Persistence Length High Order Structure Equilibrium Sedimentation Partial Specific Volume 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Henryk Eisenberg
    • 1
  1. 1.Polymer Research DepartmentThe Weizmann Institute of ScienceRehovotIsrael

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