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Epstein-Barr Virus and Immortalisation of Epithelial Cells

  • Beverly E. Griffin
Part of the NATO ASI Series book series (NSSA, volume 91)

Abstract

The association of Epstein-Barr virus (EBV) with two human malignancies, the B-cell (or Burkitt’s) lymphomas mainly of African origin, and carcinomas of the nasopharynx (NPC) common to southern China, as well as its causative role in infectious mononucleosis is well-documented (1,2). Now being recognised and deserving equal attention are the EBV-associated lymphoproliferative disorders arising in immunosuppressed persons, notably among recipients of bone-marrow, cardiac and renal transplants, many of which prove fatal (3, and references therein). In spite of the medical importance of this member of the herpes virus family, its precise role in cellular transformation has proved difficult to elucidate.

Keywords

Infectious Mononucleosis Cosmid Library African Green Monkey Kidney Cell Herpes Virus Family Burkitt Lymphoma Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Beverly E. Griffin
    • 1
  1. 1.Department of Virology, Royal Postgraduate Medical SchoolHammersmith HospitalLondonEngland

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