Immunoglobulin Genes, Oncogenes, and Human B-Cell Tumors

  • Peter C. Nowell
  • Carlo M. Croce
Part of the NATO ASI Series book series (NSSA, volume 91)


In the last several years, a combined investigative approach utilizing techniques of somatic cell genetics, molecular genetics, and cytogenetics has provided exciting preliminary evidence concerning specific genes important in the pathogenesis of human B-cell lymphomas and possible mechanisms by which their function may be altered in neoplastic cells. Burkitt’s lymphoma has provided the most information to date, but other lymphomas and leukemias are now being explored. Overall, the data are still quite limited, but the field is moving very rapidly.


Burkitt Lymphoma Immunoglobulin Gene Immunoglobulin Heavy Chain Gene Somatic Cell Genetic Burkitt Lymphoma Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Peter C. Nowell
    • 1
  • Carlo M. Croce
    • 2
  1. 1.Department of Pathology and Laboratory of MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  2. 2.The Wistar Institute of Anatomy and BiologyPhiladelphiaUSA

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