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Regulation of Gene Expression in Developmental and Oncogenic Processes: The Albumin Alpha-Fetoprotein Locus in Mammals

  • José M. Sala-Trepat
  • Anne Poliard
  • Isabelle Tratner
  • Maryse Poiret
  • Mariela Gomez-Garcia
  • Andras Gal
  • Jean-Louis Nahon
  • Monique Frain
Part of the NATO ASI Series book series (NSSA, volume 91)

Abstract

The molecular mechanisms underlying malignant cell transformation are hardly understood. An attractive hypothesis is that the acquisition of the malignant phenotype might be brought about by the activation of genes (e.g. oncogenes) whose expression is normally restricted to actively proliferating embryonic cells. Insight into the mechanisms controlling gene expression during developmental and oncogenic processes appears then essential to our understanding of neoplastic transformation.

Keywords

Adult Kidney Fetal Hepatocyte Albumin Gene Adult Hepatocyte Morris Hepatoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • José M. Sala-Trepat
    • 1
  • Anne Poliard
    • 1
  • Isabelle Tratner
    • 1
  • Maryse Poiret
    • 1
  • Mariela Gomez-Garcia
    • 1
  • Andras Gal
    • 1
  • Jean-Louis Nahon
    • 1
  • Monique Frain
    • 1
  1. 1.Laboratoire d’EnzymologieC.N.R.S.Gif-sur-YvetteFrance

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