HTLV in Adult T Cell Leukemia and Acquired Immune Deficiency Syndrome

  • Prem S. Sarin
Part of the NATO ASI Series book series (NSSA, volume 91)


The involvement of retroviruses in animal leukemias and lymphomas has been well established. Retroviruses have been isolated from several animal species including chickens, mice, cats, cows and gibbon apes (1). Leukemia induced by retroviruses in mice and cats is usually accompanied by viremia and abundant virus production. Two animal model systems, viz., the feline and bovine leukemias provide some interesting parallels with the human disease. In the feline system, the isolation of a retrovirus (FeLV) from leukemic cats, the epidemiology of the disease and induction of leukemia by this virus clearly established FeLV as the cause of the disease in cats (2,3). In the case of bovine leukosis, a disease found to cluster in cattle herds, the involvement of a virus in the causation of the disease was considered long before the isolation of bovine leukemia virus (BLV). BLV was not detected in primary leukemic cells but was expressed in cells only after short term culture. BLV has since been isolated and transmitted to permanently growing cell lines and fully characterized (4). Early attempts to isolate a retrovirus from human leukemic tissues were unsuccessful until the availability of techniques to grow T cells in culture and the recent isolation of human T cell leukemia virus (HTLV). from patients with adult T cell malignancies and acquired immune deficiency syndrome (AIDS).


Acquire Immune Deficiency Syndrome Bovine Leukemia Virus Mycosis Fungoides Hairy Cell Leukemia Human Umbilical Cord Blood 


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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Prem S. Sarin
    • 1
  1. 1.Laboratory of Tumor Cell BiologyNational Cancer InstituteBethesdaUSA

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