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Tumour-Associated Carbohydrate Antigens of Glycoproteins

  • Chapter
Investigation and Exploitation of Antibody Combining Sites

Part of the book series: Methodological Surveys in Biochemistry and Analysis ((MSBA,volume 15B))

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Abstract

Many antigens recognized by monoclonal antibodies (MAb’s) as tumour markers are carbohydrate structures related to the major blood group system. They represent an inappropriate expression of saccharide antigens for the tissues in question (e.g. due to incomplete biosynthesis). Carbohydrate structures which behave as oncofoetal antigens, and the use of modern methods of oligosaccharide separation and structural analysis in the elucidation of antigenicity, are exemplified in this article.

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Author information

Authors and Affiliations

  1. Applied Immunochemistry Research Group, MRC Clinical Research Centre, Watford Road, Harrow, Middx., HA1 3UJ, UK

    E. F. Hounsell, H. C. Gooi & T. Feizi

Authors
  1. E. F. Hounsell
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  2. H. C. Gooi
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  3. T. Feizi
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Editor information

Editors and Affiliations

  1. Guildford Academic Associates, Guildford, UK

    Eric Reid

  2. University of Cambridge, Cambridge, UK

    G. M. W. Cook

  3. Cancer Center, Purdue University, West Lafayette, Indiana, USA

    D. J. Morré

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© 1985 Plenum Press, New York

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Hounsell, E.F., Gooi, H.C., Feizi, T. (1985). Tumour-Associated Carbohydrate Antigens of Glycoproteins. In: Reid, E., Cook, G.M.W., Morré, D.J. (eds) Investigation and Exploitation of Antibody Combining Sites. Methodological Surveys in Biochemistry and Analysis, vol 15B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5006-4_38

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  • DOI: https://doi.org/10.1007/978-1-4684-5006-4_38

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5008-8

  • Online ISBN: 978-1-4684-5006-4

  • eBook Packages: Springer Book Archive

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