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Tumour-Associated Carbohydrate Antigens of Glycoproteins

  • E. F. Hounsell
  • H. C. Gooi
  • T. Feizi
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 15B)

Abstract

Many antigens recognized by monoclonal antibodies (MAb’s) as tumour markers are carbohydrate structures related to the major blood group system. They represent an inappropriate expression of saccharide antigens for the tissues in question (e.g. due to incomplete biosynthesis). Carbohydrate structures which behave as oncofoetal antigens, and the use of modern methods of oligosaccharide separation and structural analysis in the elucidation of antigenicity, are exemplified in this article.

Keywords

Carbohydrate Antigen Carbohydrate Structure Carbohydrate Chain Foetal Antigen Peanut Lectin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • E. F. Hounsell
    • 1
  • H. C. Gooi
    • 1
  • T. Feizi
    • 1
  1. 1.Applied Immunochemistry Research GroupMRC Clinical Research CentreHarrow, Middx.UK

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