Monoclonal Antibodies to Human Tumours for Targeting Cytotoxic Drugs
Monoclonal antibodies (MAb’s) reacting with human tumours provide novel approaches for targeting anti-cancer agents, as studied with MAb 791T/36 which localizes in human tumours including carcinoma of the colon and ovary and sarcomas. Localization has been evaluated initially in human tumour xenografts in immune-deprived mice and, with radiolabel in the imaging context, in patients. Ab-linked cytotoxic drugs investigated have included vindesine and methotrexate; already it appears that they significantly inhibit the growth of osteogenic sarcoma xenografts in immuno-deprived mice. The possible advantage of different Ab’s or of Ab fragments is discussed.
KeywordsOsteogenic Sarcoma Human Serum Albumin Clonogenic Assay Vinca Alkaloid Tumour Xenograft Study
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