Requirements by Cancer Cells for Polypeptide Growth Factors Suggest New Therapeutic Strategies

  • Peter Alexander
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 15B)

Abstract

Division of normal cells is evidently an adaptive response to a sequence of external signals. This often holds too for cancer cells except that they produce and release growth factors for which they bear the appropriate surface receptor, and this can result in autocrine stimulation.

Keywords

Toxicity Agar Lymphoma Sarcoma Polypeptide 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    DeLarco, J.E. & Todaro, G.J. (1978) Proc. Nat. Acad. Sci. 75, 4001–4005.CrossRefGoogle Scholar
  2. 2.
    Sporn, M.B. & Todaro, G.J. (1980) New Engl. J. Mec. 303, 878–880.CrossRefGoogle Scholar
  3. 3.
    Sporn, M.B., Anzano, M.A., Aasoian, R.K., DeLarco, J.E., Frolik, C.A., Meyers, C.A. & Roberts, A.M. (1984) Cancer Cells 1, 1.Google Scholar
  4. 4.
    Lee, D.L., Rose, T.M., Webb, N.R. & Todaro, G.J. (1985) Nature 313, 489–491.CrossRefGoogle Scholar
  5. 5.
    Alexander, P. & Currie, G.A. (1984) Biochem. Pharmacol. 33,941–943.Google Scholar
  6. 6.
    Urdal, D.L., March, C.L., Gillis, S., Larsen, A. & Dower, S.K. (1984) Proc. Nat. Acad. Sci. 81, 6481–6485.CrossRefGoogle Scholar
  7. 7.
    Murphy, P., Taylor, I. & Alexander, P. (1985) in Treatment of Metastases - Problems and Prospects (Hellman, K. & Eccles, A., eds.), Taylor & Francis, Basingstoke, pp. 195-199.Google Scholar
  8. 8.
    Alexander, P. (1983) J. Path. 141, 379–383.CrossRefGoogle Scholar
  9. 9.
    Schreiber, A.B., Lax, I., Yarden, Y., Eshar, Z. & Schlessinger, J. (1981) Proc. Nat. Acad. Sci. 78, 7535–7539.CrossRefGoogle Scholar
  10. 10.
    Garrett, J.S., Coughlin, S.R., Niman, H.L., Tremble, P.M., Giels, G.M. & Williams, L.T. (1984) Proc. Nat. Acad. Sci. 81, 7466–7470.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Peter Alexander
    • 1
  1. 1.Cancer Research Campaign Medical Oncology Unit, Southampton General HospitalUniversity of SouthamptonSouthamptonUK

Personalised recommendations