Antigen-Specific T-Cell Activation

  • Arun Fotedar
  • Michel Boyer
  • Wallace Smart
  • Bhagirath Singh
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 15B)


Extensive investigations into the phenomenon of activation of antigen-specific ‘IA’-restricted T cells have led to the emergence of two main research areas. One is antigen processing by antigen-presenting cells (APC), prior to actual presentation to T cells in the context of IA on the APC surface. The second involves the study of the ternary interaction between antigen, IA and the T cell receptor. This Note concerns some of our results which impinge on these two overlapping areas of interest. We have generated T cell hybridomas by fusing antigen-primed T-cell blasts with BW5147, using procedures essentially described earlier [1]. T-cell hybridomas specific for beef insulin [2] selected for their ability to release IL2 in the presence of appropriate APC and antigen [3] were used in these studies.


Antigen Processing Conformational Determinant Ternary Interaction Sequential Determinant Idiotypic Network 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Arun Fotedar
    • 1
  • Michel Boyer
    • 1
  • Wallace Smart
    • 1
  • Bhagirath Singh
    • 1
  1. 1.Department of Immunology MRC Group on Immunoregulation845E MSB University of AlbertaEdmontonCanada

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