Antigen-Specific T-Cell Activation
Extensive investigations into the phenomenon of activation of antigen-specific ‘IA’-restricted T cells have led to the emergence of two main research areas. One is antigen processing by antigen-presenting cells (APC), prior to actual presentation to T cells in the context of IA on the APC surface. The second involves the study of the ternary interaction between antigen, IA and the T cell receptor. This Note concerns some of our results which impinge on these two overlapping areas of interest. We have generated T cell hybridomas by fusing antigen-primed T-cell blasts with BW5147, using procedures essentially described earlier . T-cell hybridomas specific for beef insulin  selected for their ability to release IL2 in the presence of appropriate APC and antigen  were used in these studies.
KeywordsAntigen Processing Conformational Determinant Ternary Interaction Sequential Determinant Idiotypic Network
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