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Molecular Nature of the T3 Antigen of Human T Lymphocytes

  • M. J. Crumpton
  • O. P. Chilson
  • J. M. Kanellopoulos
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 15B)

Abstract

T-lymphocytes are normally quiescent but are stimulated by contact with antigen to grow, divide and differentiate into immunocompetent cells. A particular antigen, however, stimulates only the small proportion of antigen-specific T cells (usually <0.1% of the total population). Various polyclonal mitogens stimulate the majority of human T-lymphocytes, irrespective of their antigen specificity, to respond in an apparently identical manner with that induced by specific antigen. Such mitogens include the lectins Concanavalin A (Con A) and phytohaemagglutinin (PHA), and monoclonal antibodies (MAb’s) of the OKT3 series (viz. OKT3, Leu-4 and UCH-T1). One explanation for their mitogenicity is that they react with the T-cell antigen receptor, thereby promoting biochemical responses identical with those initiated by the interaction of antigen with its specific receptor.

Keywords

Antigen Receptor Combine Site Imperial Cancer Research Fund London WC2A Lectin Concanavalin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Reference

  1. 1.
    Kanellopoulos, J.M., Wigglesworth, N.M., Owen, M.J. & Crumpton, M.J. (1983) EMBO J. 2, 1807–1814.Google Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • M. J. Crumpton
    • 1
  • O. P. Chilson
    • 1
  • J. M. Kanellopoulos
    • 1
  1. 1.Imperial Cancer Research FundLincoln’s Inn FieldsLondonUK

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