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An Immunological Approach to the Cell Lineage Problem in the Mammalian CNS

  • Martin C. Raff
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 15B)

Abstract

The majority of neurons and glial cells in the mammalian CNS develop from the neuroepithelial cells that form the neural tube. But what is the lineage relationship between these different cell types and what determines whether an individual neuroepithelial cell becomes a particular type of neuron or one of the several types of glial cells?

Keywords

Glial Cell Optic Nerve Neuroepithelial Cell Lineage Relationship Immunological Approach 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Illustrative publications

  1. a.
    Raff, M.C., Abney, E.R., Cohen, J., Lindsay, R. & Noble, M. (1983) Two types of astrocytes in cultures of developing rat white matter: differences in morphology, surface gangliosides and growth characteristics. J. Neuroscience 3, 1289–1300.Google Scholar
  2. b.
    Raff, M.C., Miller, R. & Noble, M. (1983) A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on the culture medium. Nature 303, 390–396.Google Scholar
  3. c.
    Miller, R.H. & Raff, M.C. (1984) Fibrous and protoplasmic astrocytes are biochemically and developmentally distinct. J. Neurosci. 4, 585–592.Google Scholar
  4. d.
    d. Raff, M.C., Abney, E.R. & Miller, R.H. (1984) Two glial cell lineages diverge prenatally in rat optic nerve. Dev. Biol. 106, 53–60.Google Scholar
  5. e.
    Raff, M.C., Abney, E.R. & Miller, R.H. (1984) Two glial cell lineages diverge prenatally in rat optic nerve. Dev. Biol. 106, 53–60.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Martin C. Raff
    • 1
  1. 1.Medical Research Council Neuroimmunology Project Zoology DepartmentUniversity College LondonLondonUK

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