Abstract
The majority of neurons and glial cells in the mammalian CNS develop from the neuroepithelial cells that form the neural tube. But what is the lineage relationship between these different cell types and what determines whether an individual neuroepithelial cell becomes a particular type of neuron or one of the several types of glial cells?
This Forum Abstract is supplemented, in respect of approaches, by an Editor’s précis, not by author’s text (it had been agreed that none would be furnished).
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Raff, M.C., Abney, E.R., Cohen, J., Lindsay, R. & Noble, M. (1983) Two types of astrocytes in cultures of developing rat white matter: differences in morphology, surface gangliosides and growth characteristics. J. Neuroscience 3, 1289–1300.
Raff, M.C., Miller, R. & Noble, M. (1983) A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on the culture medium. Nature 303, 390–396.
Miller, R.H. & Raff, M.C. (1984) Fibrous and protoplasmic astrocytes are biochemically and developmentally distinct. J. Neurosci. 4, 585–592.
d. Raff, M.C., Abney, E.R. & Miller, R.H. (1984) Two glial cell lineages diverge prenatally in rat optic nerve. Dev. Biol. 106, 53–60.
Raff, M.C., Abney, E.R. & Miller, R.H. (1984) Two glial cell lineages diverge prenatally in rat optic nerve. Dev. Biol. 106, 53–60.
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© 1985 Plenum Press, New York
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Raff, M.C. (1985). An Immunological Approach to the Cell Lineage Problem in the Mammalian CNS. In: Reid, E., Cook, G.M.W., Morré, D.J. (eds) Investigation and Exploitation of Antibody Combining Sites. Methodological Surveys in Biochemistry and Analysis, vol 15B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5006-4_24
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DOI: https://doi.org/10.1007/978-1-4684-5006-4_24
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