Human:Mouse Antibody-Producing Transfectoma Cell Lines
A new means to generate antibodies (Ab’s) with desired antigen-specificities and biological effector functions is to create transfectoma Ab-producing cell lines. These cell lines are derived from lymphoid cell lines that have been transfected with novel immunoglobulin genes using DNA-mediated gene transfer techniques. The context is our attempts at understanding the regulation of immunoglobulin gene expression. A direct outcome of these studies has been a means of generating human Ab molecules with mouse antigen-specificities.