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Antibody Combining Sites — Past, Present and Future

  • Elvin A. Kabat
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 15B)

Abstract

Editorial note (G.M.W.C.). — During the 9th International Subcellular Methodology Forum, Dr. Kabat, as well as delivering the keynote address, celebrated his 70th birthday. Forum participants were privileged to listen to a retrospective look at the way in which our concepts of antibody combining site structure have developed over the past 50 years, from an investigator who has been intimately involved in much of this work. In this article, based on the keynote address, the reader is guided through the ways which have ultimately led to our present understanding of the sizes and shapes of antibody molecules, their specific combining sites and the genetic control of the antibody response. The author concludes with a summary of the Limitations of our present understanding and the way in which future studies are likely to develop.

Keywords

Gene Conversion Antigenic Determinant Hypervariable Region Keynote Address Antibody Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Elvin A. Kabat
    • 1
    • 2
    • 3
  1. 1.Departments of Microbiology, Human GeneticsDevelopment, and Neurology, and the Cancer CenterNew YorkUSA
  2. 2.Institute for Cancer ResearchColumbia University College of Physicians and SurgeonsNew YorkUSA
  3. 3.National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA

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