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Possible Memory Enhancing Effects of β-Carbolines

  • Patrice Venault
  • Lia Prado de Carvalho
  • Jean Rossier
  • Georges Chapouthier
Part of the Advances in Behavioral Biology book series (ABBI, volume 28)

Abstract

Methyl-β-carboline 3 carboxylate (β-CCM) is a benzodiazepine receptor ligand that has been shown to have pharmacological properties that are opposite to those of benzodiazepines in all situations tested. Thus this molecule is a convulsant whereas benzodiazepines are known anticonvulsants; β-CCM is anxiogenic whereas benzodiazepines are known anxiolytics. β-CCM can therefore be considered as an inverse agonist of benzodiazepines. Since benzodiazepines have been shown to be amnesic drugs, we have hypothetized that β-CCM could have memory enhancing effects. This hypothesis was tested in two different behavioral situations. 1 — Imprinting in chicks. According to the technique used in our laboratory, chicks placed in front of a moving decoy during an acquisition session learn to follow it. This behavior of following the decoy is tested in the same situation 24 h later (test session). When chicks were injected with β-CCM (2.5 mg/kg i.p.) before the acquisition session, following of the decoy was enhanced in the test session (without drug). On the other hand, the classical benzodiazepine diazepam (DZ) (0.25 mg/kg i.p.), administered before the acquisition session, reduced following of the decoy during the test session. 2 — Latent learning in mice.

Keywords

Test Session Food Consumption Pharmacological Property Food Depri Memory Consolidation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Soubrié, P., Simon, P., and Boissier, J.R., 1976, Amnesie induite chez le rat par les benzodiazépines lors d’une situation ne faisant pas intervenir de composante nociciptive, C. R. Acad. Sc. Paris (D), 283:203.Google Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Patrice Venault
    • 1
  • Lia Prado de Carvalho
    • 1
  • Jean Rossier
    • 1
  • Georges Chapouthier
    • 1
  1. 1.Depts I et II - Laboratoire de Physiologie NerveuseC.N.R.S.Gif-sur-YvetteFrance

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