Possible Memory Enhancing Effects of β-Carbolines
Methyl-β-carboline 3 carboxylate (β-CCM) is a benzodiazepine receptor ligand that has been shown to have pharmacological properties that are opposite to those of benzodiazepines in all situations tested. Thus this molecule is a convulsant whereas benzodiazepines are known anticonvulsants; β-CCM is anxiogenic whereas benzodiazepines are known anxiolytics. β-CCM can therefore be considered as an inverse agonist of benzodiazepines. Since benzodiazepines have been shown to be amnesic drugs, we have hypothetized that β-CCM could have memory enhancing effects. This hypothesis was tested in two different behavioral situations. 1 — Imprinting in chicks. According to the technique used in our laboratory, chicks placed in front of a moving decoy during an acquisition session learn to follow it. This behavior of following the decoy is tested in the same situation 24 h later (test session). When chicks were injected with β-CCM (2.5 mg/kg i.p.) before the acquisition session, following of the decoy was enhanced in the test session (without drug). On the other hand, the classical benzodiazepine diazepam (DZ) (0.25 mg/kg i.p.), administered before the acquisition session, reduced following of the decoy during the test session. 2 — Latent learning in mice.
KeywordsTest Session Food Consumption Pharmacological Property Food Depri Memory Consolidation
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