Fetal Brain Tissue Transplants Promote Behavioral Recovery from Bilateral Lesions of the Cerebral Cortex in Adult Rats
We recently demonstrated that frontal cortex taken from embryonic rats and transplanted directly into the damaged frontal cortex of adult animals, could dramatically improve their performance on a spatial alternation task. Implants of fetal cerebellum had no such effect. Although recovery of function was more rapid in the rats with cortical transplants, they were not able to perform the learning task as well as intact controls. Since the recovery was not complete, we decided to examine some of the factors that could enhance the effectivness of the transplants.