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An Interdisciplinary Study of the Effects of 6-OHDA Lesions of the Septum on Cholinergic Septo-Hippocampal Activity in Inbred Mouse Strains

  • Thomas Durkin
  • Daniel Galey
  • Yannick Jeantet
  • Georgeos Sifakis
  • Robert Jaffard
Part of the Advances in Behavioral Biology book series (ABBI, volume 28)

Abstract

The functional activity of the cholinergic neurones of the septohippocampal pathway has been postulated to play an important role in learning and memory processes (Jaffard and Destrade, 1982) and is transsynaptically regulated by numerous neurotransmitter systems, including dopamine, in the septum (Costa et al., 1983). A10 dopamine terminals mediate a tonic inhibitory control on these cholinergic neurones and Durkin et al. (1983) reported that significant genotypic variation exists for this dopaminergic control in the C57BL/6 and BALB/c mouse strains and that this variation may underly strain differences in learning and memory performance. We therefore decided to undertake an interdisciplinary study of the effects of 6-OHDA lesions of the lateral septum (3µg/1 µl, bilateral) in C57BL/6 and BALB/c mice. Between 6 and 12 days post-operation their alternation behaviour, acquisition, retention and reversal of a spatial learning task was tested in a T-maze and compared to vehicle-injected and intact controls. 6-OHDA injected mice exhibited higher rates of spontaneous alternation and a facilitation of both acquisition and reversal of the spatial discrimination, these facultative effects being significantly greater in C57BL/6 mice as compared to BALB/c.

Keywords

Cholinergic Neurone Spontaneous Alternation Intact Control Alternation Behaviour Lateral Septum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Costa, E., Panula, P., Thompson, H., Cheney, D., 1983, The transynaptic regulation of the septal-hippocampal cholinergic neurones. Life Sci., 32:165.CrossRefGoogle Scholar
  2. Durkin, T., Hashem-Zadeh, H., Mandel, P., Kempf, J., Ebel, A., 1983, Genotypic variation in the dopaminergic inhibitory control of striatal and hippocampal cholinergic activity in mice. Pharmacol. Biochem. Behav., 19:63.CrossRefGoogle Scholar
  3. Jaffard, R., Destrade, C., 1982, Learning and memory processes as related to genotypic or experimental variations of hippocampal cholinergic activity in inbred strains of mice, in: “The Genetics of the Brain,” E. Lieblich, Ed., Elsevier, Amsterdam.Google Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Thomas Durkin
    • 1
  • Daniel Galey
    • 1
  • Yannick Jeantet
    • 1
  • Georgeos Sifakis
    • 1
  • Robert Jaffard
    • 1
  1. 1.Laboratoire de Psychophysiologie,U.A. CNRS n° 339Univ Bordeaux ITalenceFrance

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