Functions of Nucleus Basalis Magnocellularis Input to the Neocortex: A Reconstitution Analysis Using Intracerebral Transplantation

  • Alan Fine
  • Stephen B. Dunnett
  • Guy Toniolo
Part of the Advances in Behavioral Biology book series (ABBI, volume 28)


Pharmacological studies have, over the past two decades, established the involvement of acetylcholine in learning and memory processes (Deutsch, 1971; Bartus et al., 1982). This link has been strengthened by the discovery that senile dementia of the Alzheimer’s type (SDAT), which is characterized by progressive debilitating memory loss, is associated with reduction of cholinergic markers throughout much of the neocortex and hippocampus (Bowen et al., 1976; Perry et al., 1978).


Basal Forebrain Choline Acetyltransferase Inhibitory Avoidance Ibotenic Acid Nucleus BASALIS MAGNOCELLULARIS 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Alan Fine
    • 1
  • Stephen B. Dunnett
    • 2
  • Guy Toniolo
    • 3
  1. 1.MRC Neurochemical Pharmacology Unit, Medical Research Council CentreMedical SchoolCambridgeUK
  2. 2.Department of Experimental PsychologyCambridgeUK
  3. 3.Laboratoire de Neurobiologie des ComportementsUniversite Louis PasteurStrasbourgFrance

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