Functions of Nucleus Basalis Magnocellularis Input to the Neocortex: A Reconstitution Analysis Using Intracerebral Transplantation
Pharmacological studies have, over the past two decades, established the involvement of acetylcholine in learning and memory processes (Deutsch, 1971; Bartus et al., 1982). This link has been strengthened by the discovery that senile dementia of the Alzheimer’s type (SDAT), which is characterized by progressive debilitating memory loss, is associated with reduction of cholinergic markers throughout much of the neocortex and hippocampus (Bowen et al., 1976; Perry et al., 1978).
KeywordsBasal Forebrain Choline Acetyltransferase Inhibitory Avoidance Ibotenic Acid Nucleus BASALIS MAGNOCELLULARIS
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- Dunnett, S.B., Toniolo, G., Fine, A., Björklund, A. and Iversen, S.D., ransplantation of embryonic ventral forebrain neurons to the neocortex of rats with lesions of nucleus basalis magnocellularis. II. Sensorimotor and learning impairments. Neuroscience, in press (b).Google Scholar
- Fine, A., Dunnett, S.B., Björklund, A. and Iversen, S.D. Transplantation of embryonic ventral forebrain neurons to the neocortex of rats with lesions of nucleus basalis magnocellularis. I. Anatomical and biochemical studies, Neuroscience, in press (a).Google Scholar
- Fine, A., Dunnett, S.B., Björklund, A. and Iversen, S.D. Cholinergic grafts reinnervating the neocortex improve memory in a rat model of Alzheimer’s disease, Brain Res., in press (b).Google Scholar
- Mesulam, M.M., Mufson, E.J., Levey, E.J. and Wainer, B.H., 1983, Cholinergic innervation of cortex by the basal forebrain: cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata) and hypothalamus in the rhesus monkey, J. comp. Neurol., 214:170.CrossRefGoogle Scholar
- Pearson, R.C.A., Sofroniew, M.V., Cuello, A.C., Powell, T.P.S., Eckenstein, F., Esiri, M.M. and Wilcock, G.K., 1983, Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer’s type demonstrated by immunohistochemical staining for choline acetyltransferase, Brain Res., 289:375.CrossRefGoogle Scholar