Reorganization and Restoration of Central Nervous Connections after Injury: A Lesion and Transplant Study of the Rat Hippocampus

  • Jens Zimmer
  • Niels Sunde
  • Torben Sørensen
Part of the Advances in Behavioral Biology book series (ABBI, volume 28)


The hippocampus and fascia dentata are cortical brain structures with a distinct laminar organization of both the neuronal cell layers and the terminations of extrinsic and intrinsic afferents in the neuropil. In addition, the dentate granule cells are among the latest forming neurons in the brain. It has thus been estimated that in the rat about 85% of the granule cells form after birth, mainly during the first postnatal days (Bayer, 1980). These structural and developmental features have prompted — and facilitated — a large number of studies of lesion-induced plasticity of the hippocampal and dentate nerve connections (see Cotman and Lynch, 1976; Cotman and Nadler, 1978; Zimmer, 1978; Laurberg and Zimmer, 1980, 1981; Gall and Lynch, 1980). More recently these studies have been extended to include studies of the cellular and connective organization of the hippocampus and fascia dentata after intracerebral and intraocular transplantations (Zimmer, 1978; Sunde and Zimmer, 1981, 1983; Goldowitz et al., 1982, 1984; Kromer et al., 1983; Zimmer and Sunde, 1984; Zimmer et al., 1985).


Granule Cell Mossy Fiber Perforant Path Dentate Granule Cell Mossy Fiber Terminal 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Jens Zimmer
    • 1
  • Niels Sunde
    • 1
  • Torben Sørensen
    • 1
  1. 1.Institute of Anatomy B (Neurobiology)University of AarhusAarhus CDenmark

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