Neuropeptides and Functional Recovery after Brain Damage
Recent studies have shown that systemic administration of ACTH-(1–39) can enhance functional and structural changes after crushing of peripheral nerves in the rat. Animals, having elevated ACTH-plasma lvels, due to adrenalectomy, or after peripheral ACTH-administration, recovered more quickly from disturbed foot movements (normal and heat-evoked) after nerve crush than control animals (Strand and Kung, 1980; Saint-Côme et al., 1982). Such beneficial effects of ACTH on functional recovery after peripheral nerve crush were also reported by Bijlsma and colleagues (1981). They found that sensorimotor function in rats after sciatic nerve crush was facilitated by ACTH-related peptides, especially those containing the melanotropic moiety (Bijlsma et al., 1983a). ACTH-(4–10) and the ACTH-(4–9) analogue, ORG 2766 were active in this respect, but α-MSH was shown to be the most potent peptide influencing recovery speed (Bijlsma et al., 1983a). Treatment with the N- and C-terminal parts of ORG 2766, ACTH-(4–7) and the tripeptide Phe7-D-Lys8-Phe9 (PDLP) respectively, and with ACTH-(ll-24) remained ineffective. Thus, sofar, the effective fragments having beneficial effects on recovery include those having behavioral but not adrenocortical potency.
KeywordsReversal Learning Sciatic Nerve Crush Peptide Treatment Electric Footshock Conditioned Avoidance Behavior
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