Behavioral Correlates of Plasticity in Substantia Nigra Efferents
The present chapter describes a series of experiments which deal with the relationship between recovery from lesion-induced asymmetries in behavior and changes in crossed efferents emanating from the substantia nigra. In all of these experiments rotational behavior, which subsided with time, was induced in rats. This was usually done by means of unilateral lesions to the nervous system. Connections from the substantia nigra (SN) to the contralateral nucleus caudatus (NC) and thalamus (Th) were then examined using tract tracing techniques. Horseradish peroxidase (HRP) was usually employed. It was found that the cessation of the lesion-induced turning behavior (behavioral plasticity) was associated, in time, with an increase in the number of cells in the SN that were labeled by a tract tracer injected into the contralateral NC or Th (anatomical plasticity). It was also found that prevention of the rotational behavior suppressed both the return to symmetry and the apparent increase in the crossed nigro-thalamic projections. Thus, it is possible that changes in crossed SN efferents form part of a morphological basis of recovery from asymmetrical behavior induced by unilateral nervous system lesions.
KeywordsSubstantia Nigra Rotational Behavior Fast Blue Peripheral Lesion Behavioral Recovery
Unable to display preview. Download preview PDF.
- Björklund, A., and Stenevi, U., 1979, Regeneration of monoami-nergic and cholinergic neurons in the mammalian central nervous system, Physiol. Rev., 59: 62.Google Scholar
- Cotman, C. W., Nieto-Sampedro, M., and Harris, E. W., 1981, Synapse replacement in the nervous system of adult vertebrates, Physiol. Rev., 61:684.Google Scholar
- Flohr, H., Bienhold, H., Abeln, W., and Macskovics, I., 1981, Concepts of vestibular compensation, in:“Lesion-Induced Neuronal Plasticity in Sensorimotor Systems”, H. Flohr and W. Precht, eds., Springer Verlag, New York.Google Scholar
- Fujito, Y., Tsukahara, N., Oda, Y., and Yoshida, M., 1982, Formation of functional synapses in the adult cat red nucleus from the cerebrum following cross-innervation of forelimb flexor and extensor nerves. II. analysis of newly appeared synaptic potentials, Exp. Brain Res., 45:13.CrossRefGoogle Scholar
- Goldberger, M. E., and Murray, M., 1978, Recovery of movement and axonal sprouting may obey some of the same laws, in: “Neuronal Plasticity”, C. W. Cotman, ed., Raven Press, New York.Google Scholar
- Held, R., 1968, Plasticity in sensorimotor Coordination, in: “The Neuropsychology of Spatially Oriented Behavior”, S. J. Freedman, ed., The Dorsey Press, Homewood, Ill.Google Scholar
- Johnson, D., and Alitili, C. R., 1978, Age, brain damage, and performance, in: “Recovery from Brain Damage”, S. Finger, ed., Plenum Press, New York.Google Scholar
- Merrill, E. G., and Wall, P. D., 1978, Plasticity of connection in the adult nervous system, in.: “Neuronal Plasticity”, C. W. Cotman, ed., Raven Press, New York.Google Scholar
- Ungerstedt, U., 1971, Postsynaptic supersensitivity after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system, Acta physiol. Scand. Suppl., 367:69.Google Scholar