Neocortex, Hippocampus and Performance in Lashley’s Maze III

  • Lesley C. Eames
  • David A. Oakley
Part of the Advances in Behavioral Biology book series (ABBI, volume 28)


There is now a long history of ideas and experimentation on the role of neocortex in associative learning (see reviews by Oakley, 1979a,b,; Russell, 1980). So far as Pavlovian conditioning is concerned, Pavlov himself proposed neocortex as the primary substrate of learning. Subsequent work, however, has shown that Pavlovian conditioning of heart-rate and gastrointestinal responses (DiCara, Braun and Pappas, 1970), nictitating membrane responses (Oakley and Russell, 1977) and autoshaped bar-presses (Oakley et al. 1981) is not impaired, and may even be enhanced, after removal of most or all of neocortex (neodecortication) in rats and rabbits. In the case of the conditional nictitating membrane response interest has recently centred on the cerebellum (Thompson, 1983) and in particular on cerebellar cortex (e.g. Yeo and Hardiman in this volume) as the essential substrate of the learned association. Similarly, both long-term and short-term habituation of distraction to a novel tone survive total removal of neocortex in rats (Yeo and Oakley, 1983).


Food Reward Pavlovian Conditioning Error Score Hippocampal Lesion Cortical Lesion 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Lesley C. Eames
    • 1
  • David A. Oakley
    • 1
  1. 1.Department of Psychology and Centre for NeuroscienceUniversity College LondonLondonG.B.

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