Oxytocin and Vasopressin in Memory and Amnesia

  • Gábor L. Kovács
  • Gyula Telegdy
  • Ferenc Laczi
  • Ferenc A. László
Part of the Advances in Behavioral Biology book series (ABBI, volume 28)


The pituitary gland plays a role in the acquisition and maintenance of learned behavior. Treatment of rats with lysine-vasopressin (LVP) or arginine-vasopressin (AVP) has been shown to produce a long-lasting delay in the extinction of pole-jumping (De Wied et al., 1971) and bench-jumping (Schulz et al., 1974) avoidance reactions. LVP and AVP treatments also improved passive avoidance behavior (Bohus et al., 1972, Kovács et al., 1977). De Wied et al. (De Wied 1976) suggested that memory processes might be facilitated by vasopressin. Additional evidence for effects of AVP and LVP on memory processes was provided by experiments on amnesia which indicated that these peptides prevented or reversed puromycine-, CO2- or pentylenetetrazole-induced retrograde amnesia in rats and mice (Lande et al.,.1972, Rigter et al., 1974, Bohus et al., 1982).


Memory Process Passive Avoidance Diabetes Insipidus Retrograde Amnesia Electroconvulsive Shock 


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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Gábor L. Kovács
    • 1
  • Gyula Telegdy
    • 1
  • Ferenc Laczi
    • 2
  • Ferenc A. László
    • 2
  1. 1.Institute of PathophysiologyUniversity Medical SchoolSzegedHungary
  2. 2.Endocrine Unit and Research LaboratoryUniversity Medical SchoolSzegedHungary

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