Vasopressin, Hippocampal Excitability and Paired-Pulse Potentiation

  • J. E. Smithson
  • M. W. Brown
Part of the Advances in Behavioral Biology book series (ABBI, volume 28)


The essentially simple organization of the hippocampal formation renders it well suited to electrophysiological and pharmacological studies. The basic structure comprises a trisynaptic circuit repeated in lamellar fashion along its longitudinal axis. This cellular architecture allows the extracellular recording of large evoked potentials which closely reflect events at the level of the single cell (Andersen et al., 1971). Furthermore, thin transverse sections can be prepared from the hippocampus and maintained in vitro whilst remaining functionally intact and thus providing a convenient model for the study of the actions of pharmacological agents (Langmoen and Andersen, 1981; Schwartzkroin, 1981).


Pyramidal Cell Hippocampal Slice Arginine Vasopressin Population Spike Perforant Path 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • J. E. Smithson
    • 1
  • M. W. Brown
    • 1
  1. 1.Department of Anatomy, The Medical School BristolUniversity of BristolBristolEngland

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