Effects of Central Administration of Corticosterone or Adrenalectomy in Mice on Memory and Evoked Activity in the Hippocampus
There is now a large body of evidence for corticosteroid actions on brain and behavior. Some authors have emphasized that corticosterone can play a role in adaptive behaviors, and particularly in learning and memory, through interactions with hippocampal functions (McEwen, 1979; McEwen and Micco, 1980); the hippocampus could be the major glucocorticoid target site of the central nervous system (CNS). Relations between steroids and the hippocampus have been shown in different ways, mainly in rats. Lesions or stimulations of the hippocampal system modify the pituitary adrenocortical functions (Feldman and Conforti, 1980; Feldman et al., 1982; Dunn and Orr, 1984; and review in Pfaff et al., 1971, and Bohus, 1975). Conversely, modifications of circulating corticosterone levels change morphological aspects of hippocampal neurons (Scheff and Cotman, 1982) and induce neurochemical hippocampal modifications (Etgen et al., 1979; McEwen and Micco, 1980; Nestler et al., 1981). In aging, correlations have been observed between degeneration in the hippocampus and plasma corticosterone levels (Landfield and Lynch, 1977). Moreover, steroids can modulate electrophysiological activity of the hippocampus (review in McEwen, 1979) as measured by spontaneous cell activity (Pfaff et al., 1971) as well as by commissural evoked potentials (Dana et al., 1982).
KeywordsCorticosteroid Propylene Glycol Hydrocortisone Dexamethasone
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