What does the “LTP Model of Memory” Model?

  • György Buzsáki
Part of the Advances in Behavioral Biology book series (ABBI, volume 28)


In several areas of the brain, and particularly in the hippocampal formation, short bursts of high frequency impulses result in potentiation of the responses to subsequent single pulse stimuli (Bliss and Lømo, 19 73). The potentiation may last for days, or even weeks, hence the designation long-term potentiation (LTP). Some consider this use-dependent enhancement of synaptic efficacy to be a model system for the investigation of the biological substrate of memory (Bliss and Dolphin, 1982; Goddard 1980; Voronin, 1983).


Pyramidal Cell Hippocampal Formation Slow Wave Sleep Population Spike Stratum Radiatum 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • György Buzsáki
    • 1
  1. 1.Department of PhysiologyUniversity Medical SchoolPécsHungary

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