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What does the “LTP Model of Memory” Model?

  • György Buzsáki
Part of the Advances in Behavioral Biology book series (ABBI, volume 28)

Abstract

In several areas of the brain, and particularly in the hippocampal formation, short bursts of high frequency impulses result in potentiation of the responses to subsequent single pulse stimuli (Bliss and Lømo, 19 73). The potentiation may last for days, or even weeks, hence the designation long-term potentiation (LTP). Some consider this use-dependent enhancement of synaptic efficacy to be a model system for the investigation of the biological substrate of memory (Bliss and Dolphin, 1982; Goddard 1980; Voronin, 1983).

Keywords

Pyramidal Cell Hippocampal Formation Slow Wave Sleep Population Spike Stratum Radiatum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bliss, T.V.P. and Dolphin, A.C., 1982. What is the mechanism of long-term potentiation in the hippocampus? Trends Neurosci. 5: 289.CrossRefGoogle Scholar
  2. Bliss, T.V.P. and T. Lømo, T., 1973, Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path, J. Physiol. Lond. 232:331.Google Scholar
  3. Buzsáki, G., 1984a, Long-term changes of hippocampal sharp-waves following high frequency afferent activation, Brain Res, 300:179.CrossRefGoogle Scholar
  4. Buzsáki, G. 1984b, Feed-forward inhibition in the hippooampal formation, Progr. Neurobiol. 22:131.CrossRefGoogle Scholar
  5. Buzsáki, G., Leung, L.S., and Vanderwolf, C.H., 1983, Cellular basis of hippocampal EEG in the behaving rat, Brain Res. Rev. 6:139.CrossRefGoogle Scholar
  6. Buzsáki, G., Grastyân, E., Czopf, J., Kellényi, L. and Prohaska, O., 1981. Changes in neuronal transmission in the rat hippocampus during behavior, Brain Res. 225:235.CrossRefGoogle Scholar
  7. Douglas, R.M., 1977, Long-lasting synaptic potentiation in the rat dentate gyrus following brief frequency stimulation, Brain Res. 126:361.CrossRefGoogle Scholar
  8. Eccles, J.C., 1983. Calcium in long-term potentiation as a model for memory, Neurosci. 10:1071.Google Scholar
  9. Glickman, S.W. and Schiff, B.B., 1967, A biological theory of reinforcement, Psychol. Rev. 74:81.CrossRefGoogle Scholar
  10. Goddard, G.V., 1980, Component properties of memory machines: Hebb revisited, in: “The Nature of Thought: Essays in Honour of D.O. Hebb”, P.W. Jusczyk and R.M. Klein, eds., Lawrence Erlbaum, Hillsdale, NJ.Google Scholar
  11. Grastyán, E., Szabó, I., Molnâr, P., and Kolta, P., 1968, Rebound, reinforcement and self-stimulation, Comm. Behav. Biol. 2:235.Google Scholar
  12. Jouvet, M., Michel, F., and Courjon, J., 1959, L’activite electricque du rhinencephale an cours du Sommeil chez le chat, C.R. Soc. Biol. (Paris) 15 3:101.Google Scholar
  13. Levy, W.B., and Steward, O., 1979, Synapses as associative elements in the hippocampal formation. Brain Res. 175:233.CrossRefGoogle Scholar
  14. McNaughton, B.L., Douglas, R.M., and Goddard, G.V., 1978. Synaptic enhancement in fascia dentata: cooperativity among coactive afferents, Brain Res. 157:277.CrossRefGoogle Scholar
  15. Ranck, J.B., Jr., 1973, Studies on single neurons in dorsal hippocampal formation and septum in unrestratined rats. I. Behavioral correlates and firing repertories, Exp. Neurol. 42:461.Google Scholar
  16. Sheffield, F.D., Roby, T.B., and Campbell, B.A., 1954, Drive reduction versus consummatory behavior as determinants of reinforcement, J. comp. physiol. Psychol. 47:349.CrossRefGoogle Scholar
  17. Suzuki, S.S., and Smith, G.K., 1982, Spontaneous EEG spikes the hippocampus of normal behaving rat. Soc. Neurosci. Abstr. 8:1051.Google Scholar
  18. Valenstein, E.S., Cox, V.C., and Kakolewski, J.W., 1969, The hypothalamus and motivated behavior, in: “Reinforcement and behavior” J.T. Tapp, ed. Academic Press, New York.Google Scholar
  19. Voronin, L.L., 1983. Long-term potentiation in the hippocampus, Neurosci. 10:1051.CrossRefGoogle Scholar
  20. Winson, J. and Abzug, C., 1978, Neuronal transmission through hippocampal pathways dependent on behavior. J. Neurophysiol. 41:716.Google Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • György Buzsáki
    • 1
  1. 1.Department of PhysiologyUniversity Medical SchoolPécsHungary

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