Hippocampal Mossy Fiber Distribution and Two-Way Avoidance Learning in Rats and Mice
The genetic basis of animal learning has been studied extensively in the last two decades. Extensive overviews have been provided by Fuller and Thompson (1978) and Wimer and Wimer (1984). Our group in Heidelberg has previously studied these problems by investigating different behavioral parameters such as two-way avoidance performance, water-maze learning, and operant conditioning in mice (Buselmaier et al., 1982; Schwegler and Buselmaier, 1982). Using a classical mendelian and a half-diallel cross we were able to establish a clear genetic basis for shuttle-box and water-T-maze learning in mice. The next step was to determine the neurobiological correlates of these differences in learning.
KeywordsMossy Fiber Dentate Granule Cell Avoidance Acquisition Hippocampal Mossy Fiber Mossy Fiber Terminal
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